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Association of a va...
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Lopez-Vicario, C
(author)
Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2017-11-16
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Springer Science and Business Media LLC,2017
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:137049584
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http://kipublications.ki.se/Default.aspx?queryparsed=id:137049584URI
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https://doi.org/10.1038/s41598-017-15951-zDOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Obesity comorbidities are closely associated with chronic low-grade adipose tissue inflammation. A number of SNPs associated with inflammation has been identified, underscoring the impact of genetic determinants on this process. Here, we screened SNPs in genes with pro-inflammatory (IL-1β, IL-6, STAT3 and JAK2), anti-inflammatory (IL-10 and SOCS3) and pro-resolving (ERV1/ChemR23) properties in 101 obese and 99 non-obese individuals. Among the SNPs analyzed, we identified that individuals carrying a C allele in the rs1878022 polymorphism of the ERV1/ChemR23 gene, which encodes for the receptor of the pro-resolving mediator RvE1, had increased ERV1/ChemR23 protein expression and reduced levels of the inflammatory cytokine IL-6 in adipose tissue. Moreover, patients carrying the C allele in homozygosity had lower plasma levels of IL-6, IFN-α2, IL-15, IL-1ra, IL-10, GM-CSF, G-CSF and VEGF and enhanced leukocyte responsiveness to RvE1. C-carriers also exhibited decreased TAG to HDL ratio, a surrogate marker of insulin resistance and a predictor of incident fatty liver. Finally, we confirmed in vivo that the ERV1/ChemR23 receptor regulates systemic and tissue inflammation since mice lacking ERV1/ChemR23 expression showed increased IL-6 levels in adipose tissue and peritoneal macrophages. Together, our study identified an ERV1/ChemR23 variant that protects patients with obesity from excessive inflammatory burden.
Added entries (persons, corporate bodies, meetings, titles ...)
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Rius, B
(author)
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Alcaraz-Quiles, J
(author)
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Gonzalez-Periz, A
(author)
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Martinez-Puchol, AI
(author)
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Casulleras, M
(author)
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Duran-Guell, M
(author)
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Ibarzabal, A
(author)
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Corcelles, R
(author)
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Laguna-Fernandez, A
(author)
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Back, MKarolinska Institutet
(author)
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Titos, E
(author)
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Claria, J
(author)
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Karolinska Institutet
(creator_code:org_t)
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In:Scientific reports: Springer Science and Business Media LLC7:1, s. 15724-2045-2322
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Duran-Guell, M
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