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Inhibition of C1-Te...
Inhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways
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Jeong, H (author)
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Koh, A (author)
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Lee, J (author)
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Park, D (author)
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Lee, JO (author)
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Lee, MN (author)
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Jo, KJ (author)
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Tran, HNK (author)
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Kim, E (author)
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Min, BS (author)
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Kim, HS (author)
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- Berggren, PO (author)
- Karolinska Institutet
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Ryu, SH (author)
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(creator_code:org_t)
- 2017-12-19
- 2017
- English.
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In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1, s. 17777-
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Abstract
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- Insulin resistance causes type 2 diabetes; therefore, increasing insulin sensitivity is a therapeutic approach against type 2 diabetes. Activating AMP-activated protein kinase (AMPK) is an effective approach for treating diabetes, and reduced insulin receptor substrate-1 (IRS-1) protein levels have been suggested as a molecular mechanism causing insulin resistance. Thus, dual targeting of AMPK and IRS-1 might provide an ideal way to treat diabetes. We found that 15,16-dihydrotanshinone I (DHTS), as a C1-Ten protein tyrosine phosphatase inhibitor, increased IRS-1 stability, improved glucose tolerance and reduced muscle atrophy. Identification of DHTS as a C1-Ten inhibitor revealed a new function of C1-Ten in AMPK inhibition, possibly through regulation of IRS-1. These findings suggest that C1-Ten inhibition by DHTS could provide a novel therapeutic strategy for insulin resistance-associated metabolic syndrome through dual targeting of IRS-1 and AMPK.
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- art (subject category)
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- By the author/editor
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Jeong, H
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Koh, A
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Lee, J
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Park, D
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Lee, JO
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Lee, MN
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show more...
-
Jo, KJ
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Tran, HNK
-
Kim, E
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Min, BS
-
Kim, HS
-
Berggren, PO
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Ryu, SH
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show less...
- Articles in the publication
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Scientific repor ...
- By the university
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Karolinska Institutet