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Expression Levels of the Uridine-Cytidine Kinase Like-1 Protein As a Novel Prognostic Factor for Hepatitis C Virus-Associated Hepatocellular Carcinomas
- Buivydiene, A (author)
- Liakina, V (author)
- Valantinas, J (author)
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- Norkuniene, J (author)
- Mockiene, E (author)
- Jokubauskiene, S (author)
- Smaliukiene, R (author)
- Jancoriene, L (author)
- Kovalevska, L (author)
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- (creator_code:org_t)
- 2017-09-15
- 2017
- English.
- In: Acta naturae. - : Acta Naturae Ltd. - 2075-8251. ; 9:3, s. 108-114
- Journal article (peer-reviewed)
Abstract
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- The expression levels of the two novel oncoproteins uridine-cytidine kinase like-1 (UCKL-1) and mitochondrial ribosomal protein S18-2 (MRPS18-2) were assessed in samples of hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) using immunohistochemistry. Tissue microarray (TMA) paraffin blocks were prepared from 42 HCC tumor samples with the corresponding peri-tumor tissues and from 11 tissues of a liver with HCV-induced cirrhosis. We found that the UCKL-1 signal in the liver tissues of the peri-tumor zone in the HCC samples was stronger than that in cirrhosis (50 49.44 vs. 24.27 14.53; p = 0.014). The MRPS18-2 expression was weak, and there was no differences between the groups (p = 0.26). Noteworthy, the UCKL-1 protein was expressed at higher levels in peri-tumor tissues in the cases of HCC recurrence; this was confirmed for 27 older patients (63.78 9.22 vs. 53.53 4.07 years, p 0.001), in parallel with enhanced UCKL-1 staining in former HCC nodules (62.69 50.4 vs. 26.0 30.19, p = 0.006) and microvascular invasion (p = 0.02). A multivariate analysis of prognostic factors for HCC recurrence showed that the best predictive factors for these conditions were UCKL-1 expression in tumor, vascular invasion, and HCC treatment modality, other than liver transplantation (odds ratios: 1.029, 18.143 and 11.984, R = 0.633, p = 0.002). In conclusion, the high UCKL-1 expression might be a prognostic factor for HCC relapse, in combination with age and microvascular invasion. MRPS18-2 protein expression has no prognostic significance in the cases of HCV-associated HCC.
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- Buivydiene, A
- Liakina, V
- Valantinas, J
- Norkuniene, J
- Mockiene, E
- Jokubauskiene, S
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- Smaliukiene, R
- Jancoriene, L
- Kovalevska, L
- Kashuba, E
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- Karolinska Institutet
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