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Converging epidemic...
Converging epidemics of sexually transmitted infections and bacterial vaginosis in southern African female adolescents at risk of HIV
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Barnabas, SL (author)
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Dabee, S (author)
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Passmore, JAS (author)
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Jaspan, HB (author)
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Lewis, DA (author)
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Jaumdally, SZ (author)
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Gamieldien, H (author)
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Masson, L (author)
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Muller, E (author)
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Maseko, VD (author)
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Mkhize, N (author)
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Mbulawa, Z (author)
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Williamson, AL (author)
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Gray, CM (author)
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Hope, TJ (author)
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- Chiodi, F (author)
- Karolinska Institutet
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Dietrich, J (author)
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Gray, G (author)
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Bekker, LG (author)
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(creator_code:org_t)
- 2017-12-04
- 2018
- English.
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In: International journal of STD & AIDS. - : SAGE Publications. - 1758-1052 .- 0956-4624. ; 29:6, s. 531-539
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https://doi.org/10.1...
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Abstract
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- Adolescents in Africa are at high risk for HIV infection, other sexually transmitted infections (STIs) and bacterial vaginosis (BV). Since behavior and burden of STIs/BV may influence HIV risk, behavioral risk factors and prevalence of STIs/BV were compared in HIV-seronegative adolescent females (n = 298; 16–22 years) from two South African communities (Soweto and Cape Town). STIs ( Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma genitalium, herpes simplex virus (HSV)-1, HSV-2, Treponema pallidum, and Haemophilus ducreyi) were detected by multiplex polymerase chain reaction, human papillomavirus (HPV) by Roche Linear Array, and BV by Nugent scoring. Rates of BV (Nugent ≥7; 46.6%) and HPV (66.8%) were high in both communities. Prevalence of C. trachomatis and N. gonorrhoeae were >2-fold higher in Cape Town than Soweto (Chlamydia: 42% [62/149] versus 18% [26/148], p < 0.0001; gonorrhoea 11% [17/149] versus 5% [7/148], p = 0.05). Only 24% of adolescents with vaginal discharge-causing STIs or BV were symptomatic. In South African adolescents, clinical symptoms compatible with vaginal discharge syndrome had a sensitivity of 23% and specificity of 85% for the diagnosis of discharge-causing STI or BV. In a region with high HIV prevalence and incidence, >70% of young women with treatable conditions that could enhance HIV risk would have been missed because they lacked symptoms associated with syndromic management.
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- By the author/editor
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Barnabas, SL
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Dabee, S
-
Passmore, JAS
-
Jaspan, HB
-
Lewis, DA
-
Jaumdally, SZ
-
show more...
-
Gamieldien, H
-
Masson, L
-
Muller, E
-
Maseko, VD
-
Mkhize, N
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Mbulawa, Z
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Williamson, AL
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Gray, CM
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Hope, TJ
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Chiodi, F
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Dietrich, J
-
Gray, G
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Bekker, LG
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show less...
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International jo ...
- By the university
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Karolinska Institutet