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Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
- Huckins, LM (author)
- Hatzikotoulas, K (author)
- Southam, L (author)
- show more...
- Thornton, LM (author)
- Steinberg, J (author)
- Aguilera-McKay, F (author)
- Treasure, J (author)
- Schmidt, U (author)
- Gunasinghe, C (author)
- Romero, A (author)
- Curtis, C (author)
- Rhodes, D (author)
- Moens, J (author)
- Kalsi, G (author)
- Dempster, D (author)
- Leung, R (author)
- Keohane, A (author)
- Burghardt, R (author)
- Ehrlich, S (author)
- Hebebrand, J (author)
- Hinney, A (author)
- Ludolph, A (author)
- Walton, E (author)
- Deloukas, P (author)
- Hofman, A (author)
- Palotie, A (author)
- Palta, P (author)
- van Rooij, FJA (author)
- Stirrups, K (author)
- Adan, R (author)
- Boni, C (author)
- Cone, R (author)
- Dedoussis, G (author)
- van Furth, E (author)
- Gonidakis, F (author)
- Gorwood, P (author)
- Hudson, J (author)
- Kaprio, J (author)
- Kas, M (author)
- Keski-Rahonen, A (author)
- Kiezebrink, K (author)
- Knudsen, GP (author)
- Slof-Op 't Landt, MCT (author)
- Maj, M (author)
- Monteleone, AM (author)
- Monteleone, P (author)
- Raevuori, AH (author)
- Reichborn-Kjennerud, T (author)
- Tozzi, F (author)
- Tsitsika, A (author)
- van Elburg, A (author)
- Collier, DA (author)
- Breen, G (author)
- Zeggini, E (author)
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- (creator_code:org_t)
- 2017-07-25
- 2018
- English.
- In: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 23:5, s. 1169-1180
- Journal article (peer-reviewed)
Abstract
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- Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls. Unlike previous studies, this GWAS also probed association in low-frequency and rare variants. Sixteen independent variants were taken forward for in silico and de novo replication (11 common and 5 rare). No findings reached genome-wide significance. Two notable common variants were identified: rs10791286, an intronic variant in OPCML (P=9.89 × 10−6), and rs7700147, an intergenic variant (P=2.93 × 10−5). No low-frequency variant associations were identified at genome-wide significance, although the study was well-powered to detect low-frequency variants with large effect sizes, suggesting that there may be no AN loci in this genomic search space with large effect sizes.
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- art (subject category)
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- By the author/editor
- Huckins, LM
- Hatzikotoulas, K
- Southam, L
- Thornton, LM
- Steinberg, J
- Aguilera-McKay, ...
- show more...
- Treasure, J
- Schmidt, U
- Gunasinghe, C
- Romero, A
- Curtis, C
- Rhodes, D
- Moens, J
- Kalsi, G
- Dempster, D
- Leung, R
- Keohane, A
- Burghardt, R
- Ehrlich, S
- Hebebrand, J
- Hinney, A
- Ludolph, A
- Walton, E
- Deloukas, P
- Hofman, A
- Palotie, A
- Palta, P
- van Rooij, FJA
- Stirrups, K
- Adan, R
- Boni, C
- Cone, R
- Dedoussis, G
- van Furth, E
- Gonidakis, F
- Gorwood, P
- Hudson, J
- Kaprio, J
- Kas, M
- Keski-Rahonen, A
- Kiezebrink, K
- Knudsen, GP
- Slof-Op 't Landt ...
- Maj, M
- Monteleone, AM
- Monteleone, P
- Raevuori, AH
- Reichborn-Kjenne ...
- Tozzi, F
- Tsitsika, A
- van Elburg, A
- Collier, DA
- Sullivan, PF
- Breen, G
- Bulik, CM
- Zeggini, E
- show less...
- Articles in the publication
- Molecular psychi ...
- By the university
- Karolinska Institutet
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