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  • Zhou, AUniv South Australia, Australian Ctr Precis Hlth, Adelaide, SA, Australia (author)

Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-05-14
  • Springer Science and Business Media LLC,2018

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:138268170
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138268170URI
  • https://doi.org/10.1038/s41598-018-25919-2DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-356867URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Coffee’s long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian randomization to investigate the causal relationship between habitual coffee consumption and cognitive function in mid- to later life. This included up to 415,530 participants and 300,760 coffee drinkers from 10 meta-analysed European ancestry cohorts. In each cohort, composite cognitive scores that capture global cognition and memory were computed using available tests. A genetic score derived using CYP1A1/2 (rs2472297) and AHR (rs6968865) was chosen as a proxy for habitual coffee consumption. Null associations were observed when examining the associations of the genetic score with global and memory cognition (β = −0.0007, 95% C.I. −0.009 to 0.008, P = 0.87; β = −0.001, 95% C.I. −0.005 to 0.002, P = 0.51, respectively), with high consistency between studies (Pheterogeneity > 0.4 for both). Domain specific analyses using available cognitive measures in the UK Biobank also did not support effects by habitual coffee intake for reaction time, pairs matching, reasoning or prospective memory (P ≥ 0.05 for all). Despite the power to detect very small effects, our meta-analysis provided no evidence for causal long-term effects of habitual coffee consumption on global cognition or memory.

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  • Taylor, AEUniv Bristol, MRC Integrat Epidemiol Unit IEU, Bristol, Avon, England;Univ Bristol, UKCTAS, Bristol, Avon, England;Univ Bristol, Sch Expt Psychol, Bristol, Avon, England (author)
  • Karhunen, VUniv Oulu, Ctr Life Course Hlth Res, Oulu, Finland;Oulu Univ Hosp, Oulu, Finland (author)
  • Zhan, YQKarolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden (author)
  • Sjögren, PerUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)persj732 (author)
  • Lahti, JHelsinki Collegium Adv Studies, Helsinki, Finland;Univ Helsinki, Dept Psychol & Logoped, Fac Med, Helsinki, Finland (author)
  • Sjogren, P (author)
  • Byberg, LiisaUppsala universitet,Ortopedi(Swepub:uu)liisbybe (author)
  • Lyall, DMUniv Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland (author)
  • Auvinen, JUniv Oulu, Ctr Life Course Hlth Res, Oulu, Finland;Oulu Univ Hosp, Unit Primary Hlth Care, Oulu, Finland (author)
  • Lehtimaki, TUniv Tampere, Fac Med & Life Sci, Fimlab Labs, Dept Clin Chem, Tampere, Finland;Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Tampere, Finland (author)
  • Kahonen, MUniv Tampere, Dept Clin Physiol, Tampere Univ Hosp, Tampere, Finland;Univ Tampere, Fac Med & Life Sci, Tampere, Finland (author)
  • Hutri-Kahonen, NUniv Tampere, Fac Med & Life Sci, Tampere, Finland;Univ Tampere, Tampere Univ Hosp, Dept Pediat, Tampere, Finland (author)
  • Perala, MMNatl Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland (author)
  • Michaëlsson, Karl,1959-Uppsala universitet,Ortopedi(Swepub:uu)karlmich (author)
  • Mahajan, AWellcome Ctr Human Genet, Nuffield Dept Med, Oxford OX3 7BN, England (author)
  • Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden(Swepub:uu)larslind (author)
  • Power, CUCL Great Ormond St Inst Child Hlth, Populat Policy & Practice, London WC1N 1EH, England (author)
  • Eriksson, JGUniv Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland;Folkhalsan Res Ctr, Helsinki, Finland (author)
  • Raitakari, OTUniv Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland;Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland (author)
  • Hagg, SKarolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden (author)
  • Pedersen, NLKarolinska Institutet (author)
  • Veijola, JUniv Oulu, Dept Psychiat, Res Unit Clin Neurosci, Oulu, Finland;Univ Hosp Oulu, Dept Psychiat, Oulu, Finland (author)
  • Jarvelin, MRUniv Oulu, Ctr Life Course Hlth Res, Oulu, Finland;Oulu Univ Hosp, Unit Primary Hlth Care, Oulu, Finland;Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, London, England;Univ Oulu, Bioctr Oulu, Oulu, Finland (author)
  • Munafo, MRUniv Bristol, MRC Integrat Epidemiol Unit IEU, Bristol, Avon, England;Univ Bristol, UKCTAS, Bristol, Avon, England;Univ Bristol, Sch Expt Psychol, Bristol, Avon, England (author)
  • Ingelsson, Erik,1975-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Stanford Univ, Div Cardiovasc Med, Dept Med, Sch Med, Stanford, CA 94305 USA;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA(Swepub:uu)ering425 (author)
  • Llewellyn, DJUniv Exeter, Med Sch, Exeter, Devon, England (author)
  • Hypponen, EUniv South Australia, Australian Ctr Precis Hlth, Adelaide, SA, Australia;UCL Great Ormond St Inst Child Hlth, Populat Policy & Practice, London WC1N 1EH, England;South Australian Hlth & Med Res Inst, Adelaide, SA, Australia (author)
  • Univ South Australia, Australian Ctr Precis Hlth, Adelaide, SA, AustraliaUniv Bristol, MRC Integrat Epidemiol Unit IEU, Bristol, Avon, England;Univ Bristol, UKCTAS, Bristol, Avon, England;Univ Bristol, Sch Expt Psychol, Bristol, Avon, England (creator_code:org_t)

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  • In:Scientific reports: Springer Science and Business Media LLC8:1, s. 7526-2045-2322

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