onr:"swepub:oai:prod.swepub.kib.ki.se:138391840"
Search: onr:"swepub:oai:prod.swepub.kib.ki.se:138391840" > Immunization with H...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Ahmadi, M (author)
Immunization with HER2 extracellular subdomain proteins induces cellular response and tumor growth inhibition in mice
- Article/chapterEnglish2018
Publisher, publication year, extent ...
- Future Medicine Ltd,2018
Numbers
- LIBRIS-ID:oai:prod.swepub.kib.ki.se:138391840
- http://kipublications.ki.se/Default.aspx?queryparsed=id:138391840URI
- https://doi.org/10.2217/imt-2017-0181DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Aim: We investigated cellular and protective immune responses in mice vaccinated with recombinant HER2 extracellular subdomains. Materials & methods: Balb/C mice were immunized with recombinant full HER2 extracellular domain and subdomain proteins. Humoral and cellular immune response and antitumor effect was evaluated using a syngeneic mice tumor model. Results: All recombinant proteins induced secretion of IL-4 and particularly IFN-γ and IL-17 cytokines. Challenging of immunized mice with stable 4T1-HER2 transfected cells resulted in partial but significant tumor growth inhibition in all groups of mice particularly those immunized with fHER2-ECD together with CPG. Conclusion: Our results suggest that the recombinant HER2-ECD subdomains induce mainly Th1 and Th17 responses, which seem to contribute to tumor growth inhibition in syngeneic mice.
Added entries (persons, corporate bodies, meetings, titles ...)
- Sadri-Ardalani, F (author)
- Amiri, MM (author)
- Jeddi-Tehrani, MKarolinska Institutet (author)
- Shabani, M (author)
- Shokri, F (author)
- Karolinska Institutet (creator_code:org_t)
Related titles
- In:Immunotherapy: Future Medicine Ltd10:6, s. 511-5241750-74481750-743X
Internet link
Find in a library
- Immunotherapy (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Ahmadi, M
- Sadri-Ardalani, ...
- Amiri, MM
- Jeddi-Tehrani, M
- Shabani, M
- Shokri, F
- Articles in the publication
- Immunotherapy
- By the university
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
