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Immunization with H...
Immunization with HER2 extracellular subdomain proteins induces cellular response and tumor growth inhibition in mice
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Ahmadi, M (author)
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Sadri-Ardalani, F (author)
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Amiri, MM (author)
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- Jeddi-Tehrani, M (author)
- Karolinska Institutet
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Shabani, M (author)
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Shokri, F (author)
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(creator_code:org_t)
- Future Medicine Ltd, 2018
- 2018
- English.
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In: Immunotherapy. - : Future Medicine Ltd. - 1750-7448 .- 1750-743X. ; 10:6, s. 511-524
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http://kipublication...
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https://doi.org/10.2...
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Abstract
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- Aim: We investigated cellular and protective immune responses in mice vaccinated with recombinant HER2 extracellular subdomains. Materials & methods: Balb/C mice were immunized with recombinant full HER2 extracellular domain and subdomain proteins. Humoral and cellular immune response and antitumor effect was evaluated using a syngeneic mice tumor model. Results: All recombinant proteins induced secretion of IL-4 and particularly IFN-γ and IL-17 cytokines. Challenging of immunized mice with stable 4T1-HER2 transfected cells resulted in partial but significant tumor growth inhibition in all groups of mice particularly those immunized with fHER2-ECD together with CPG. Conclusion: Our results suggest that the recombinant HER2-ECD subdomains induce mainly Th1 and Th17 responses, which seem to contribute to tumor growth inhibition in syngeneic mice.
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