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Anticancer chemothe...
Anticancer chemotherapy and radiotherapy trigger both non-cell-autonomous and cell-autonomous death
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Martins, I (author)
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Raza, SQ (author)
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Voisin, L (author)
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Dakhli, H (author)
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Allouch, A (author)
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Law, F (author)
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Sabino, D (author)
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De Jong, D (author)
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Thoreau, M (author)
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Mintet, E (author)
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Dugue, D (author)
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Piacentini, M (author)
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Gougeon, ML (author)
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Jaulin, F (author)
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Bertrand, P (author)
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Brenner, C (author)
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Ojcius, DM (author)
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Kroemer, G (author)
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Modjtahedi, N (author)
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Deutsch, E (author)
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Perfettini, JL (author)
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- 2018-06-18
- 2018
- English.
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In: Cell death & disease. - : Springer Science and Business Media LLC. - 2041-4889. ; 9:7, s. 716-
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Even though cell death modalities elicited by anticancer chemotherapy and radiotherapy have been extensively studied, the ability of anticancer treatments to induce non-cell-autonomous death has never been investigated. By means of multispectral imaging flow-cytometry-based technology, we analyzed the lethal fate of cancer cells that were treated with conventional anticancer agents and co-cultured with untreated cells, observing that anticancer agents can simultaneously trigger cell-autonomous and non-cell-autonomous death in treated and untreated cells. After ionizing radiation, oxaliplatin, or cisplatin treatment, fractions of treated cancer cell populations were eliminated through cell-autonomous death mechanisms, while other fractions of the treated cancer cells engulfed and killed neighboring cells through non-cell-autonomous processes, including cellular cannibalism. Under conditions of treatment with paclitaxel, non-cell-autonomous and cell-autonomous death were both detected in the treated cell population, while untreated neighboring cells exhibited features of apoptotic demise. The transcriptional activity of p53 tumor-suppressor protein contributed to the execution of cell-autonomous death, yet failed to affect the non-cell-autonomous death by cannibalism for the majority of tested anticancer agents, indicating that the induction of non-cell-autonomous death can occur under conditions in which cell-autonomous death was impaired. Altogether, these results reveal that chemotherapy and radiotherapy can induce both non-cell-autonomous and cell-autonomous death of cancer cells, highlighting the heterogeneity of cell death responses to anticancer treatments and the unsuspected potential contribution of non-cell-autonomous death to the global effects of anticancer treatment.
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- art (subject category)
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- By the author/editor
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Martins, I
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Raza, SQ
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Voisin, L
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Dakhli, H
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Allouch, A
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Law, F
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show more...
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Sabino, D
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De Jong, D
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Thoreau, M
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Mintet, E
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Dugue, D
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Piacentini, M
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Gougeon, ML
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Jaulin, F
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Bertrand, P
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Brenner, C
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Ojcius, DM
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Kroemer, G
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Modjtahedi, N
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Deutsch, E
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Perfettini, JL
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show less...
- Articles in the publication
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Cell death & dis ...
- By the university
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Karolinska Institutet