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A multi-ethnic meta...
A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis
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Kou, I (author)
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Watanabe, K (author)
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Takahashi, Y (author)
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Momozawa, Y (author)
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Khanshour, A (author)
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Grauers, A (author)
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Zhou, H (author)
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Liu, G (author)
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Fan, YH (author)
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Takeda, K (author)
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Ogura, Y (author)
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Zhou, TF (author)
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Iwasaki, Y (author)
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Kubo, M (author)
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Wu, ZH (author)
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Matsumoto, M (author)
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Einarsdottir, E (author)
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- Kere, J (author)
- Karolinska Institutet
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Huang, DS (author)
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Qiu, GX (author)
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Qiu, Y (author)
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Wise, CA (author)
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Song, YQ (author)
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Wu, N (author)
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Su, PQ (author)
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- Gerdhem, P (author)
- Karolinska Institutet
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Ikegawa, S (author)
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(creator_code:org_t)
- 2018-08-01
- 2018
- English.
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In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1, s. 11575-
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associated with AIS. Among them is a locus on chromosome 6q24.1 that we identified by a GWAS in a Japanese cohort. The locus is represented by rs6570507 located within GPR126. To ensure the association of rs6570507 with AIS, we conducted a meta-analysis using eight cohorts from East Asia, Northern Europe and USA. The analysis included a total of 6,873 cases and 38,916 controls and yielded significant association (combined P = 2.95 × 10−20; odds ratio = 1.22), providing convincing evidence of the worldwide association between rs6570507 and AIS susceptibility. In silico analyses strongly suggested that GPR126 is a susceptibility gene at this locus.
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- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Kou, I
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Watanabe, K
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Takahashi, Y
-
Momozawa, Y
-
Khanshour, A
-
Grauers, A
-
show more...
-
Zhou, H
-
Liu, G
-
Fan, YH
-
Takeda, K
-
Ogura, Y
-
Zhou, TF
-
Iwasaki, Y
-
Kubo, M
-
Wu, ZH
-
Matsumoto, M
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Einarsdottir, E
-
Kere, J
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Huang, DS
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Qiu, GX
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Qiu, Y
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Wise, CA
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Song, YQ
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Wu, N
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Su, PQ
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Gerdhem, P
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Ikegawa, S
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show less...
- Articles in the publication
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Scientific repor ...
- By the university
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Karolinska Institutet