Search: onr:"swepub:oai:prod.swepub.kib.ki.se:139028587" >
Identification of n...
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O'Mara, TAQIMR Berghofer Medical Research Institute
(author)
Identification of nine new susceptibility loci for endometrial cancer
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-08-09
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Springer Science and Business Media LLC,2018
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:139028587
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http://kipublications.ki.se/Default.aspx?queryparsed=id:139028587URI
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https://doi.org/10.1038/s41467-018-05427-7DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-368158URI
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https://lup.lub.lu.se/record/9b22f688-0605-4a6c-a1c4-ea27adeb923fURI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Glubb, DM
(author)
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Amant, F
(author)
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Annibali, D
(author)
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Ashton, K
(author)
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Attia, J
(author)
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Auer, PL
(author)
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Beckmann, MW
(author)
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Black, A
(author)
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Bolla, MK
(author)
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Brauch, H
(author)
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Brenner, H
(author)
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Brinton, L
(author)
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Buchanan, DD
(author)
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Burwinkel, B
(author)
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Chang-Claude, J
(author)
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Chanock, SJ
(author)
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Chen, C
(author)
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Chen, MM
(author)
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Cheng, THT
(author)
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Clarke, CL
(author)
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Clendenning, M
(author)
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Cook, LS
(author)
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Couch, FJ
(author)
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Cox, A
(author)
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Crous-Bous, M
(author)
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Czene, KKarolinska Institutet
(author)
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Day, F
(author)
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Dennis, J
(author)
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Depreeuw, J
(author)
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Doherty, JA
(author)
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Dork, T
(author)
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Dowdy, SC
(author)
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Durst, M
(author)
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Ekici, AB
(author)
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Fasching, PA
(author)
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Fridley, BL
(author)
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Friedenreich, CM
(author)
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Fritschi, L
(author)
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Fung, J
(author)
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Garcia-Closas, M
(author)
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Gaudet, MM
(author)
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Giles, GG
(author)
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Goode, EL
(author)
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Gorman, M
(author)
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Haiman, CA
(author)
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Hall, PKarolinska Institutet
(author)
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Hankison, SE
(author)
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Healey, CS
(author)
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Hein, A
(author)
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Hillemanns, P
(author)
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Hodgson, S
(author)
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Hoivik, EA
(author)
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Holliday, EG
(author)
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Hopper, JL
(author)
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Hunter, DJ
(author)
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Jones, A
(author)
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Krakstad, C
(author)
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Kristensen, VN
(author)
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Lambrechts, D
(author)
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Le Marchand, L
(author)
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Liang, XL
(author)
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Lindblom, AKarolinska Institutet
(author)
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Lissowska, J
(author)
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Long, JR
(author)
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Lu, LG
(author)
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Magliocco, AM
(author)
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Martin, L
(author)
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McEvoy, M
(author)
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Meindl, A
(author)
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Michailidou, K
(author)
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Milne, RL
(author)
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Mints, MKarolinska Institutet
(author)
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Montgomery, GW
(author)
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Nassir, R
(author)
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Olsson, HåkanLund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Lund Melanoma Study Group,Lund University Research Groups(Swepub:lu)onk-hol
(author)
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Orlow, I
(author)
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Otton, G
(author)
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Palles, C
(author)
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Perry, JRB
(author)
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Peto, J
(author)
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Pooler, L
(author)
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Prescott, J
(author)
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Proietto, T
(author)
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Rebbeck, TR
(author)
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Risch, HA
(author)
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Wolk, AlicjaUppsala universitet,Ortopedi(Swepub:uu)alwol516
(author)
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Rubner, M
(author)
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Runnebaum, I
(author)
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Sacerdote, C
(author)
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Sarto, GE
(author)
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Schumacher, F
(author)
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Scott, RJ
(author)
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Setiawan, VW
(author)
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Shah, M
(author)
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Sheng, X
(author)
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Shu, XO
(author)
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Southey, MC
(author)
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Swerdlow, AJ
(author)
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Tham, EKarolinska Institutet
(author)
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Trovik, J
(author)
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Turman, C
(author)
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Tyrer, JP
(author)
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Vachon, C
(author)
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Vanden Berg, D
(author)
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Vanderstichele, A
(author)
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Wang, ZM
(author)
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Webb, PM
(author)
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Wentzensen, N
(author)
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Werner, HMJ
(author)
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Winham, SJ
(author)
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Wolk, AKarolinska Institutet
(author)
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Xia, L
(author)
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Xiang, YB
(author)
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Yang, HP
(author)
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Yu, H
(author)
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Zheng, W
(author)
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Pharoah, PDP
(author)
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Dunning, AM
(author)
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Kraft, P
(author)
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De Vivo, I
(author)
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Tomlinson, I
(author)
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Easton, DF
(author)
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Spurdle, AB
(author)
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Thompson, DJUniversity of Cambridge
(author)
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Karolinska InstitutetQIMR Berghofer Medical Research Institute
(creator_code:org_t)
Related titles
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In:Nature communications: Springer Science and Business Media LLC9:1, s. 3166-2041-1723
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Find in a library
To the university's database
- By the author/editor
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O'Mara, TA
-
Glubb, DM
-
Amant, F
-
Annibali, D
-
Ashton, K
-
Attia, J
-
show more...
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Auer, PL
-
Beckmann, MW
-
Black, A
-
Bolla, MK
-
Brauch, H
-
Brenner, H
-
Brinton, L
-
Buchanan, DD
-
Burwinkel, B
-
Chang-Claude, J
-
Chanock, SJ
-
Chen, C
-
Chen, MM
-
Cheng, THT
-
Clarke, CL
-
Clendenning, M
-
Cook, LS
-
Couch, FJ
-
Cox, A
-
Crous-Bous, M
-
Czene, K
-
Day, F
-
Dennis, J
-
Depreeuw, J
-
Doherty, JA
-
Dork, T
-
Dowdy, SC
-
Durst, M
-
Ekici, AB
-
Fasching, PA
-
Fridley, BL
-
Friedenreich, CM
-
Fritschi, L
-
Fung, J
-
Garcia-Closas, M
-
Gaudet, MM
-
Giles, GG
-
Goode, EL
-
Gorman, M
-
Haiman, CA
-
Hall, P
-
Hankison, SE
-
Healey, CS
-
Hein, A
-
Hillemanns, P
-
Hodgson, S
-
Hoivik, EA
-
Holliday, EG
-
Hopper, JL
-
Hunter, DJ
-
Jones, A
-
Krakstad, C
-
Kristensen, VN
-
Lambrechts, D
-
Le Marchand, L
-
Liang, XL
-
Lindblom, A
-
Lissowska, J
-
Long, JR
-
Lu, LG
-
Magliocco, AM
-
Martin, L
-
McEvoy, M
-
Meindl, A
-
Michailidou, K
-
Milne, RL
-
Mints, M
-
Montgomery, GW
-
Nassir, R
-
Olsson, Håkan
-
Orlow, I
-
Otton, G
-
Palles, C
-
Perry, JRB
-
Peto, J
-
Pooler, L
-
Prescott, J
-
Proietto, T
-
Rebbeck, TR
-
Risch, HA
-
Wolk, Alicja
-
Rubner, M
-
Runnebaum, I
-
Sacerdote, C
-
Sarto, GE
-
Schumacher, F
-
Scott, RJ
-
Setiawan, VW
-
Shah, M
-
Sheng, X
-
Shu, XO
-
Southey, MC
-
Swerdlow, AJ
-
Tham, E
-
Trovik, J
-
Turman, C
-
Tyrer, JP
-
Vachon, C
-
Vanden Berg, D
-
Vanderstichele, ...
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Wang, ZM
-
Webb, PM
-
Wentzensen, N
-
Werner, HMJ
-
Winham, SJ
-
Wolk, A
-
Xia, L
-
Xiang, YB
-
Yang, HP
-
Yu, H
-
Zheng, W
-
Pharoah, PDP
-
Dunning, AM
-
Kraft, P
-
De Vivo, I
-
Tomlinson, I
-
Easton, DF
-
Spurdle, AB
-
Thompson, DJ
-
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Karolinska Institutet
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Uppsala University
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Lund University