onr:"swepub:oai:prod.swepub.kib.ki.se:139472351"
Search: onr:"swepub:oai:prod.swepub.kib.ki.se:139472351" > Adhesion to nanofib...
- 1 of 1
- Previous record
- Next record
- To hitlist
Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting
- Charles-Orszag, A (author)
- Tsai, FC (author)
- Bonazzi, D (author)
- show more...
- Manriquez, V (author)
- Sachse, M (author)
- Mallet, A (author)
- Salles, A (author)
- Staneva, R (author)
- Bertin, A (author)
- Millien, C (author)
- Goussard, S (author)
- Lafaye, P (author)
- Shorte, S (author)
- Piel, M (author)
- Krijnse-Locker, J (author)
- Brochard-Wyart, F (author)
- Bassereau, P (author)
- Dumenil, G (author)
- show less...
- (creator_code:org_t)
- 2018-10-25
- 2018
- English.
- In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 4450-
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The shape of cellular membranes is highly regulated by a set of conserved mechanisms that can be manipulated by bacterial pathogens to infect cells. Remodeling of the plasma membrane of endothelial cells by the bacterium Neisseria meningitidis is thought to be essential during the blood phase of meningococcal infection, but the underlying mechanisms are unclear. Here we show that plasma membrane remodeling occurs independently of F-actin, along meningococcal type IV pili fibers, by a physical mechanism that we term ‘one-dimensional’ membrane wetting. We provide a theoretical model that describes the physical basis of one-dimensional wetting and show that this mechanism occurs in model membranes interacting with nanofibers, and in human cells interacting with extracellular matrix meshworks. We propose one-dimensional wetting as a new general principle driving the interaction of cells with their environment at the nanoscale that is diverted by meningococci during infection.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Nature communications (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Charles-Orszag, ...
- Tsai, FC
- Bonazzi, D
- Manriquez, V
- Sachse, M
- Mallet, A
- show more...
- Salles, A
- Melican, K
- Staneva, R
- Bertin, A
- Millien, C
- Goussard, S
- Lafaye, P
- Shorte, S
- Piel, M
- Krijnse-Locker, ...
- Brochard-Wyart, ...
- Bassereau, P
- Dumenil, G
- show less...
- Articles in the publication
- Nature communica ...
- By the university
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
