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Pharmacogenetic imp...
Pharmacogenetic impact of docetaxel on neoadjuvant treatment of breast cancer patients
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Sim, S (author)
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- Bergh, J (author)
- Karolinska Institutet
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Hellstrom, M (author)
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- Hatschek, T (author)
- Karolinska Institutet
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- Xie, HJ (author)
- Karolinska Institutet
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(creator_code:org_t)
- Future Medicine Ltd, 2018
- 2018
- English.
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In: Pharmacogenomics. - : Future Medicine Ltd. - 1744-8042 .- 1462-2416. ; 19:16, s. 1259-1268
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https://doi.org/10.2...
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Abstract
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- Aim: This study aimed to investigate the effect of CYP3A4 and CYP3A5 genotypes on clinical outcomes of docetaxel treatment. Patients & methods: In the PROMIX trial, 150 breast cancer patients received docetaxel preoperatively. CYP3A4 and CYP3A5 genotype combinations were transformed into total CYP 3A phenotypes. Results: Seven patients were characterized as poor metabolizer (PM), 22 patients as extensive metabolizer and 121 patients as intermediate metabolizer. The frequency of grade 3/grade 4 adverse events was higher in the PM group (p = 0.002). One PM subject who basically lacked enzyme activity died from typhlitis. Total 45 recurrences were reported after a median of 5-year follow-up; none of these was PM. Conclusion: The allelic variants CYP3A4*22 and CYP3A5*3 contribute to the interpatient variations of docetaxel.
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- ref (subject category)
- art (subject category)
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