Search: onr:"swepub:oai:prod.swepub.kib.ki.se:13990368" >
Associations betwee...
Associations between the CYBA 242C/T and the MPO -463G/A polymorphisms, oxidative stress and cardiovascular disease in chronic kidney disease patients
-
Grahl, DA (author)
-
- Axelsson, J (author)
- Karolinska Institutet
-
- Nordfors, L (author)
- Karolinska Institutet
-
show more...
-
- Heimburger, O (author)
- Karolinska Institutet
-
- Barany, P (author)
- Karolinska Institutet
-
- Qureshi, AR (author)
- Karolinska Institutet
-
Kato, S (author)
-
Watanabe, M (author)
-
- Suliman, M (author)
- Karolinska Institutet
-
Riella, MC (author)
-
- Lindholm, B (author)
- Karolinska Institutet
-
- Stenvinkel, P (author)
- Karolinska Institutet
-
Pecoits, R (author)
-
show less...
-
(creator_code:org_t)
- 2007-03-01
- 2007
- English.
-
In: Blood purification. - : S. Karger AG. - 1421-9735 .- 0253-5068. ; 25:2, s. 210-218
- Related links:
-
http://kipublication...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Genetic variations in the NADPH/MPO system in chronic kidney disease (CKD) patients might lead to altered activity of these enzymes, and thus to altered risk for oxidative stress (OS) and cardiovascular disease (CVD). We evaluated the impact of 242C/T <i>CYBA</i> and –463G/A <i>MPO</i> polymorphisms on OS and CVD mortality in stage 5 CKD patients starting dialysis. Two hundred and fifty-seven patients were genotyped using Pyrosequencing. Plasmalogen [dimethylacetal (DMA) 16/C16:0] was used as OS marker. CVD was assessed from patient history and clinical symptoms. Prevalence of CVD was higher (35%) in GG patients (<i>MPO</i>) compared to AG (26%) and AA (0%) patients (p < 0.01). Patients with CC genotype (<i>CYBA</i>) had lower levels of DMA 16/C16:0 (ratio 0.071 ± 0.003) compared to TT patients (0.089 ± 0.006; p < 0.05). These patients also had increased CVD mortality compared to CT and TT patients (χ<sup>2</sup> 2.19; p < 0.05). We conclude that genetic variations in the NADPH/MPO system are associated with OS, presence of CVD and CVD-related mortality in CKD patients.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Grahl, DA
-
Axelsson, J
-
Nordfors, L
-
Heimburger, O
-
Barany, P
-
Qureshi, AR
-
show more...
-
Kato, S
-
Watanabe, M
-
Suliman, M
-
Riella, MC
-
Lindholm, B
-
Stenvinkel, P
-
Pecoits, R
-
show less...
- Articles in the publication
-
Blood purificati ...
- By the university
-
Karolinska Institutet