Search: onr:"swepub:oai:prod.swepub.kib.ki.se:140070864" >
Multi-ancestry stud...
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Kilpelainen, TOUniversity of Copenhagen,Icahn School of Medicine at Mount Sinai
(author)
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-01-22
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London :Springer Science and Business Media LLC,2019
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:140070864
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http://kipublications.ki.se/Default.aspx?queryparsed=id:140070864URI
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https://doi.org/10.1038/s41467-018-08008-wDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-156317URI
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https://lup.lub.lu.se/record/ddccdd28-505a-425f-bbb9-5250d5206f47URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.
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Bentley, AR
(author)
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Noordam, R
(author)
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Sung, YJ
(author)
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Schwander, K
(author)
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Winkler, TW
(author)
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Jakupovic, H
(author)
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Chasman, DI
(author)
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Manning, A
(author)
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Ntalla, I
(author)
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Aschard, H
(author)
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Brown, MR
(author)
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de las Fuentes, LKarolinska Institutet
(author)
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Franceschini, N
(author)
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Guo, XQ
(author)
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Vojinovic, D
(author)
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Aslibekyan, S
(author)
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Feitosa, MF
(author)
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Kho, MKarolinska Institutet
(author)
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Musani, SK
(author)
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Richard, M
(author)
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Wang, HM
(author)
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Wang, Z
(author)
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Bartz, TM
(author)
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Bielak, LF
(author)
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Campbell, A
(author)
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Dorajoo, R
(author)
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Fisher, V
(author)
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Franks, PaulUmeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,University of Oxford,Harvard University(Swepub:lu)med-plf
(author)
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Horimoto, ARVR
(author)
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Li, CW
(author)
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Lohman, KK
(author)
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Marten, J
(author)
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Sim, XL
(author)
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Smith, AV
(author)
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Tajuddin, SM
(author)
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Alver, M
(author)
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Amini, M
(author)
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Boissel, M
(author)
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Chai, JF
(author)
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Chen, XKarolinska Institutet
(author)
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Divers, J
(author)
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Evangelou, E
(author)
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Gao, CWashington University in St. Louis
(author)
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Graff, M
(author)
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Harris, SE
(author)
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He, MA
(author)
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Hsu, FC
(author)
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Jackson, AU
(author)
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Zhao, JH
(author)
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Kraja, AT
(author)
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Kuhnel, B
(author)
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Laguzzi, FKarolinska Institutet
(author)
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Lyytikainen, LPKarolinska Institutet
(author)
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Nolte, IM
(author)
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Rauramaa, R
(author)
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Riaz, M
(author)
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Robino, A
(author)
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Rueedi, R
(author)
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Stringham, HM
(author)
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Takeuchi, F
(author)
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van der Most, PJ
(author)
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V. Varga, TiborLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-tv_
(author)
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Verweij, N
(author)
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Ware, EB
(author)
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Wen, WQ
(author)
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Li, XY
(author)
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Yanek, LR
(author)
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Amin, N
(author)
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Arnett, DK
(author)
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Boerwinkle, E
(author)
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Brumat, M
(author)
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Cade, B
(author)
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Canouil, M
(author)
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Chen, YDI
(author)
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Concas, MP
(author)
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Connell, J
(author)
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de Mutsert, R
(author)
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de Silva, HJ
(author)
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de Vries, PS
(author)
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Demirkan, A
(author)
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Ding, JZ
(author)
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Eaton, CB
(author)
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Faul, JD
(author)
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Friedlander, Y
(author)
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Gabriel, KP
(author)
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Ghanbari, M
(author)
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Giulianini, F
(author)
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Gu, CC
(author)
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Gu, DF
(author)
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Harris, TB
(author)
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He, J
(author)
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Heikkinen, S
(author)
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Heng, CK
(author)
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Hunt, SC
(author)
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Ikram, MA
(author)
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Jonas, JB
(author)
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Wennberg, Patrik,1972-Umeå universitet,Allmänmedicin(Swepub:umu)pawe0002
(author)
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Komulainen, P
(author)
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Krieger, JE
(author)
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Kritchevsky, SB
(author)
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Kutalik, Z
(author)
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Kuusisto, J
(author)
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Langefeld, CD
(author)
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Langenberg, C
(author)
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Launer, LJ
(author)
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Leander, KKarolinska Institutet
(author)
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Lemaitre, RN
(author)
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Lewis, CE
(author)
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Liang, JJ
(author)
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Alizadeh, BZ
(author)
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Boezen, HM
(author)
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Franke, LIcahn School of Medicine at Mount Sinai
(author)
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Navis, G
(author)
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Rots, M
(author)
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Swertz, M
(author)
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Wolffenbuttel, BHR
(author)
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Wijmenga, C
(author)
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Liu, JJ
(author)
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Magi, R
(author)
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Manichaikul, A
(author)
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Meitinger, T
(author)
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Metspalu, A
(author)
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Milaneschi, Y
(author)
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Mohlke, KL
(author)
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Mosley, TH
(author)
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Murray, AD
(author)
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Nalls, MA
(author)
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Nang, EEK
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Nelson, CP
(author)
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Nona, S
(author)
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Norris, JM
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Nwuba, CV
(author)
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O'Connell, J
(author)
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Palmer, ND
(author)
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Papanicolau, GJ
(author)
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Pazoki, R
(author)
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Pedersen, NLKarolinska Institutet
(author)
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Peters, A
(author)
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Poveda, AlaitzLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-azp
(author)
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Polasek, O
(author)
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Porteous, DJ
(author)
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Poveda, A
(author)
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Raitakari, OT
(author)
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Rich, SS
(author)
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Risch, N
(author)
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Robinson, JG
(author)
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Rose, LM
(author)
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Rudan, I
(author)
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Schreiner, PJ
(author)
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Scott, RA
(author)
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Sidney, SS
(author)
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Sims, M
(author)
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Smith, JA
(author)
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Snieder, H
(author)
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Sofer, T
(author)
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Starr, JM
(author)
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Sternfeld, B
(author)
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Strauch, K
(author)
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Tang, H
(author)
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Taylor, KD
(author)
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Tsai, MY
(author)
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Tuomilehto, J
(author)
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Uitterlinden, AG
(author)
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van der Ende, MY
(author)
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van Heemst, D
(author)
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Voortman, T
(author)
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Waldenberger, M
(author)
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Franks, Paul W.Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden; Harvard T. H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, USA; OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK(Swepub:umu)pafr0003
(author)
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Wilson, G
(author)
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Xiang, YB
(author)
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Yao, J
(author)
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Yu, CZ
(author)
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Yuan, JM
(author)
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Zhao, W
(author)
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Zonderman, AB
(author)
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Becker, DM
(author)
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Boehnke, M
(author)
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Bowden, DW
(author)
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de Faire, UKarolinska Institutet
(author)
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Deary, IJ
(author)
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Elliott, P
(author)
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Esko, T
(author)
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Freedman, BI
(author)
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Froguel, P
(author)
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Gasparini, P
(author)
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Gieger, C
(author)
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Kato, N
(author)
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Laakso, M
(author)
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Lakka, TA
(author)
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Lehtimaki, T
(author)
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Magnusson, PKEKarolinska Institutet
(author)
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Oldehinkel, AJ
(author)
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Penninx, BWJH
(author)
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Samani, NJ
(author)
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Shu, XO
(author)
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van der Harst, P
(author)
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Van Vliet-Ostaptchouk, JV
(author)
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Vollenweider, P
(author)
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Wagenknecht, LE
(author)
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Wang, YX
(author)
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Wareham, NJ
(author)
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Weir, DR
(author)
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Wu, TC
(author)
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Zheng, W
(author)
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Zhu, XF
(author)
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Evans, MK
(author)
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Franks, PW
(author)
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Gudnason, V
(author)
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Hayward, C
(author)
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Horta, BL
(author)
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Kelly, TN
(author)
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Liu, YM
(author)
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North, KE
(author)
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Pereira, AC
(author)
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Ridker, PM
(author)
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Tai, ES
(author)
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van Dam, RM
(author)
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Fox, ER
(author)
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Kardia, SLR
(author)
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Liu, CT
(author)
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Mook-Kanamori, DO
(author)
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Province, MA
(author)
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Redline, S
(author)
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van Duijn, CM
(author)
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Rotter, JI
(author)
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Kooperberg, CB
(author)
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Gauderman, WJ
(author)
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Psaty, BM
(author)
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Rice, K
(author)
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Munroe, PB
(author)
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Fornage, M
(author)
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Cupples, LA
(author)
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Rotimi, CN
(author)
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Morrison, AC
(author)
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Rao, DC
(author)
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Loos, RJF
(author)
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University of CopenhagenIcahn School of Medicine at Mount Sinai
(creator_code:org_t)
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et al.
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In:Nature communicationsLondon : Springer Science and Business Media LLC10:1, s. 376-2041-1723
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- By the author/editor
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Kilpelainen, TO
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Bentley, AR
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Noordam, R
-
Sung, YJ
-
Schwander, K
-
Winkler, TW
-
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Jakupovic, H
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Chasman, DI
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Manning, A
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Ntalla, I
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Aschard, H
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Brown, MR
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de las Fuentes, ...
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Franceschini, N
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Guo, XQ
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Vojinovic, D
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Aslibekyan, S
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Feitosa, MF
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Kho, M
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Musani, SK
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Richard, M
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Wang, HM
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Wang, Z
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Bartz, TM
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Bielak, LF
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Campbell, A
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Dorajoo, R
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Fisher, V
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Franks, Paul
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Horimoto, ARVR
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Li, CW
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Lohman, KK
-
Marten, J
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Sim, XL
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Smith, AV
-
Tajuddin, SM
-
Alver, M
-
Amini, M
-
Boissel, M
-
Chai, JF
-
Chen, X
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Divers, J
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Evangelou, E
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Gao, C
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Graff, M
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Harris, SE
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He, MA
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Hsu, FC
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Jackson, AU
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Zhao, JH
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Kraja, AT
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Kuhnel, B
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Laguzzi, F
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Lyytikainen, LP
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Nolte, IM
-
Rauramaa, R
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Riaz, M
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Robino, A
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Rueedi, R
-
Stringham, HM
-
Takeuchi, F
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van der Most, PJ
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V. Varga, Tibor
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Verweij, N
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Ware, EB
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Wen, WQ
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Li, XY
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Yanek, LR
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Amin, N
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Arnett, DK
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Boerwinkle, E
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Brumat, M
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Cade, B
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Canouil, M
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Chen, YDI
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Concas, MP
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Connell, J
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de Mutsert, R
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de Silva, HJ
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de Vries, PS
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Demirkan, A
-
Ding, JZ
-
Eaton, CB
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Faul, JD
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Friedlander, Y
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Gabriel, KP
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Ghanbari, M
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Giulianini, F
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Gu, CC
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Gu, DF
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Harris, TB
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He, J
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Heikkinen, S
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Heng, CK
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Hunt, SC
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Ikram, MA
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Jonas, JB
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Wennberg, Patrik ...
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Komulainen, P
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Krieger, JE
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Kritchevsky, SB
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Kutalik, Z
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Kuusisto, J
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Langefeld, CD
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Langenberg, C
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Launer, LJ
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Leander, K
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Lemaitre, RN
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Lewis, CE
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Liang, JJ
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Alizadeh, BZ
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Boezen, HM
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Franke, L
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Navis, G
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Rots, M
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Swertz, M
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Wolffenbuttel, B ...
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Wijmenga, C
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Liu, JJ
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Magi, R
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Manichaikul, A
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Meitinger, T
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Metspalu, A
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Milaneschi, Y
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Mohlke, KL
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Mosley, TH
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Murray, AD
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Nalls, MA
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Nang, EEK
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Nelson, CP
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Nona, S
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Norris, JM
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Nwuba, CV
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O'Connell, J
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Palmer, ND
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Papanicolau, GJ
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Pazoki, R
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Pedersen, NL
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Peters, A
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Poveda, Alaitz
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Polasek, O
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Porteous, DJ
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Poveda, A
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Raitakari, OT
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Rich, SS
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Risch, N
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Robinson, JG
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Rose, LM
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Rudan, I
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Schreiner, PJ
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Scott, RA
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Sidney, SS
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Sims, M
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Smith, JA
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Snieder, H
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Sofer, T
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Starr, JM
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Sternfeld, B
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Strauch, K
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Tang, H
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Taylor, KD
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Tsai, MY
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Tuomilehto, J
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Uitterlinden, AG
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van der Ende, MY
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van Heemst, D
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Voortman, T
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Waldenberger, M
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Franks, Paul W.
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Wilson, G
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Xiang, YB
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Yao, J
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Yu, CZ
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Yuan, JM
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Zhao, W
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Zonderman, AB
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Becker, DM
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Boehnke, M
-
Bowden, DW
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de Faire, U
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Deary, IJ
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Elliott, P
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Esko, T
-
Freedman, BI
-
Froguel, P
-
Gasparini, P
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Gieger, C
-
Kato, N
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Laakso, M
-
Lakka, TA
-
Lehtimaki, T
-
Magnusson, PKE
-
Oldehinkel, AJ
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Penninx, BWJH
-
Samani, NJ
-
Shu, XO
-
van der Harst, P
-
Van Vliet-Ostapt ...
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Vollenweider, P
-
Wagenknecht, LE
-
Wang, YX
-
Wareham, NJ
-
Weir, DR
-
Wu, TC
-
Zheng, W
-
Zhu, XF
-
Evans, MK
-
Franks, PW
-
Gudnason, V
-
Hayward, C
-
Horta, BL
-
Kelly, TN
-
Liu, YM
-
North, KE
-
Pereira, AC
-
Ridker, PM
-
Tai, ES
-
van Dam, RM
-
Fox, ER
-
Kardia, SLR
-
Liu, CT
-
Mook-Kanamori, D ...
-
Province, MA
-
Redline, S
-
van Duijn, CM
-
Rotter, JI
-
Kooperberg, CB
-
Gauderman, WJ
-
Psaty, BM
-
Rice, K
-
Munroe, PB
-
Fornage, M
-
Cupples, LA
-
Rotimi, CN
-
Morrison, AC
-
Rao, DC
-
Loos, RJF
-
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