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The flavonoid 4,4'-...
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Carmona-Gutierrez, D
(author)
The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-02-19
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Springer Science and Business Media LLC,2019
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:140300822
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http://kipublications.ki.se/Default.aspx?queryparsed=id:140300822URI
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https://doi.org/10.1038/s41467-019-08555-wDOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural and pharmacological interventions with feasible potential to promote health upon ageing remain rare. Here we report the identification of the flavonoid 4,4′-dimethoxychalcone (DMC) as a natural compound with anti-ageing properties. External DMC administration extends the lifespan of yeast, worms and flies, decelerates senescence of human cell cultures, and protects mice from prolonged myocardial ischaemia. Concomitantly, DMC induces autophagy, which is essential for its cytoprotective effects from yeast to mice. This pro-autophagic response induces a conserved systemic change in metabolism, operates independently of TORC1 signalling and depends on specific GATA transcription factors. Notably, we identify DMC in the plant Angelica keiskei koidzumi, to which longevity- and health-promoting effects are ascribed in Asian traditional medicine. In summary, we have identified and mechanistically characterised the conserved longevity-promoting effects of a natural anti-ageing drug.
Added entries (persons, corporate bodies, meetings, titles ...)
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Zimmermann, A
(author)
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Kainz, K
(author)
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Pietrocola, F
(author)
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Chen, G
(author)
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Maglioni, S
(author)
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Schiavi, A
(author)
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Nah, J
(author)
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Mertel, S
(author)
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Beuschel, CB
(author)
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Castoldi, F
(author)
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Sica, V
(author)
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Trausinger, G
(author)
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Raml, R
(author)
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Sommer, C
(author)
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Schroeder, S
(author)
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Hofer, SJ
(author)
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Bauer, MA
(author)
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Pendl, T
(author)
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Tadic, J
(author)
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Dammbrueck, C
(author)
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Hu, ZH
(author)
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Ruckenstuhl, C
(author)
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Eisenberg, T
(author)
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Durand, S
(author)
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Bossut, N
(author)
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Aprahamian, F
(author)
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Abdellatif, M
(author)
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Sedej, S
(author)
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Enot, DP
(author)
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Wolinski, H
(author)
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Dengjel, J
(author)
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Kepp, O
(author)
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Magnes, C
(author)
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Sinner, F
(author)
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Pieber, TR
(author)
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Sadoshima, J
(author)
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Ventura, N
(author)
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Sigrist, SJ
(author)
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Kroemer, G
(author)
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Madeo, F
(author)
Related titles
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In:Nature communications: Springer Science and Business Media LLC10:1, s. 651-2041-1723
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Carmona-Gutierre ...
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Zimmermann, A
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Kainz, K
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Pietrocola, F
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Chen, G
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Maglioni, S
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show more...
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Schiavi, A
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Nah, J
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Mertel, S
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Beuschel, CB
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Castoldi, F
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Sica, V
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Trausinger, G
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Raml, R
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Sommer, C
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Schroeder, S
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Hofer, SJ
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Bauer, MA
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Pendl, T
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Tadic, J
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Dammbrueck, C
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Hu, ZH
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Ruckenstuhl, C
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Eisenberg, T
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Durand, S
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Bossut, N
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Aprahamian, F
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Abdellatif, M
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Sedej, S
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Enot, DP
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Wolinski, H
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Dengjel, J
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Kepp, O
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Magnes, C
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Sinner, F
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Pieber, TR
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Sadoshima, J
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Ventura, N
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Sigrist, SJ
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Kroemer, G
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Madeo, F
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Karolinska Institutet