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Molecular underpinn...
Molecular underpinnings of clinical disparity patterns in African American vs. Caucasian American multiple myeloma patients
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Kazandjian, D (author)
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Hill, E (author)
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- Hultcrantz, M (author)
- Karolinska Institutet
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Rustad, EH (author)
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Yellapantula, V (author)
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Akhlaghi, T (author)
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Korde, N (author)
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Mailankody, S (author)
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Dew, A (author)
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Papaemmanuil, E (author)
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Maric, I (author)
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Kwok, M (author)
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Landgren, O (author)
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(creator_code:org_t)
- 2019-02-04
- 2019
- English.
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In: Blood cancer journal. - : Springer Science and Business Media LLC. - 2044-5385. ; 9:2, s. 15-
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Abstract
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- Caucasian Americans (CA) compared with African Americans (AA) have a twofold increased incidence of multiple myeloma (MM) and have an earlier age of diagnosis. However, there is sparse information regarding underlying biological differences across racial/ethnic groups. We characterized genetic alterations using a targeted next-generation sequencing assay called myTYPE, developed at MSKCC, allowing capture of somatic mutations, IgH translocations, gains/losses, and hyperdiploidy. Samples were obtained from the NIH Plasma Cell Dyscrasia Racial Disparity Cohort. In total, 68 patient samples were successfully sequenced and manually curated based on well-established databases. Of the 68 patient samples (47 CA, 21 AA), 84% had at least one type of genomic alteration. Importantly, the IgH translocation, t(11;14), was observed more frequently in the AA group (0 vs. 29%, p = 0.001). Known oncogenic somatic non-synonymous mutations were found in 18 genes and indels in 2 genes. KRAS mutations were the most common mutation found in 16% of patients followed by NRAS and BRAF mutations. TP53 somatic mutations appeared to be more common in CA but lacked significance. This proof-of-principle study indicates the presence of varying underlying tumor biology between racial groups and supports the need of future prospective trials to capture these molecular characteristics.
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- art (subject category)
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- By the author/editor
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Kazandjian, D
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Hill, E
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Hultcrantz, M
-
Rustad, EH
-
Yellapantula, V
-
Akhlaghi, T
-
show more...
-
Korde, N
-
Mailankody, S
-
Dew, A
-
Papaemmanuil, E
-
Maric, I
-
Kwok, M
-
Landgren, O
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show less...
- Articles in the publication
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Blood cancer jou ...
- By the university
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Karolinska Institutet