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Salivary IgA to MAA...
Salivary IgA to MAA-LDL and Oral Pathogens Are Linked to Coronary Disease
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Akhi, R (author)
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Wang, C (author)
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Nissinen, AE (author)
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Kankaanpaa, J (author)
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Bloigu, R (author)
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Paju, S (author)
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Mantyla, P (author)
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- Buhlin, K (author)
- Karolinska Institutet
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Sinisalo, J (author)
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Pussinen, PJ (author)
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Horkko, S (author)
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(creator_code:org_t)
- 2019-01-22
- 2019
- English.
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In: Journal of dental research. - : SAGE Publications. - 1544-0591 .- 0022-0345. ; 98:3, s. 296-303
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https://helda.helsin...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- A large body of literature has established the link between periodontal disease and cardiovascular disease. Oxidized low-density lipoproteins (OxLDLs) have a crucial role in atherosclerosis progression through initiation of immunological response. Monoclonal IgM antibodies to malondialdehyde-modified low-density lipoprotein (MDA-LDL) and to malondialdehyde acetaldehyde–modified low-density lipoprotein (MAA-LDL) have been shown to cross-react with the key virulence factors of periodontal pathogens Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. We have previously shown that salivary IgA antibodies to MAA-LDL cross-react with P. gingivalis in healthy humans. In this study, we aim to assess whether oral mucosal immune response represented by salivary IgA to MAA-LDL and oral pathogens is associated with coronary artery disease (CAD). Also, the molecular mimicry through antibody cross-reaction between salivary IgA to MAA-LDL and oral pathogens was evaluated. The study subjects consisted of 451 patients who underwent a coronary angiography with no CAD ( n = 133), stable CAD ( n = 169), and acute coronary syndrome (ACS, n = 149). Elevated salivary IgA antibody levels to MAA-LDL, Rgp44 (gingipain A hemagglutinin domain of P. gingivalis), and Aa-HSP60 (heat shock protein 60 of A. actinomycetemcomitans) were discovered in stable-CAD and ACS patients when compared to no-CAD patients. In a multinomial regression model adjusted for known cardiovascular risk factors, stable CAD and ACS were associated with IgA to MAA-LDL ( P = 0.016, P = 0.043), Rgp44 ( P = 0.012, P = 0.004), Aa-HSP60 ( P = 0.032, P = 0.030), Tannerella forsythia ( P = 0.002, P = 0.004), Porphyromonas endodontalis ( P = 0.016, P = 0.020), Prevotella intermedia ( P = 0.038, P = 0.005), and with total IgA antibody concentration ( P = 0.002, P = 0.016). Salivary IgA to MAA-LDL showed cross-reactivity with the oral pathogens tested in the study patients. The study highlights an association between salivary IgA to MAA-LDL and atherosclerosis. However, whether salivary IgA to MAA-LDL and the related oral humoral responses play a causal role in the development in the CAD should be elucidated in the future.
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- By the author/editor
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Akhi, R
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Wang, C
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Nissinen, AE
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Kankaanpaa, J
-
Bloigu, R
-
Paju, S
-
show more...
-
Mantyla, P
-
Buhlin, K
-
Sinisalo, J
-
Pussinen, PJ
-
Horkko, S
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show less...
- Articles in the publication
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Journal of denta ...
- By the university
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Karolinska Institutet