Search: onr:"swepub:oai:prod.swepub.kib.ki.se:140591566" >
Plasma Aβ42/40 Rati...
-
Perez-Grijalba, V
(author)
Plasma Aβ42/40 Ratio Detects Early Stages of Alzheimer's Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study
- Article/chapterEnglish2019
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:140591566
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:140591566URI
-
https://doi.org/10.14283/jpad.2018.41DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Background: Easily accessible biomarkers are needed for the early identification of individuals at risk of developing Alzheimer’s disease (AD) in large population screening strategies. Objectives: This study evaluated the potential of plasma β-amyloid (Aβ) biomarkers in identifying early stages of AD and predicting cognitive decline over the following two years. Design: Total plasma Aβ42/40 ratio (TP42/40) was determined in 83 cognitively normal individuals (CN) and 145 subjects with amnestic mild cognitive impairment (a-MCI) stratified by an FDG-PET AD-risk pattern. Results: Significant lower TP42/40 ratio was found in a-MCI patients compared to CN. Moreover, a-MCIs with a high-risk FDG-PET pattern for AD showed even lower plasma ratio levels. Low TP42/40 at baseline increased the risk of progression to dementia by 70%. Furthermore, TP42/40 was inversely associated with neocortical amyloid deposition (measured with PiB-PET) and was concordant with the AD biomarker profile in cerebrospinal fluid (CSF). Conclusions: TP42/40 demonstrated value in the identification of individuals suffering a-MCI, in the prediction of progression to dementia, and in the detection of underlying AD pathology revealed by FDG-PET, Amyloid-PET and CSF biomarkers, being, thus, consistently associated with all the well-established indicators of AD.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Romero, J
(author)
-
Pesini, P
(author)
-
Sarasa, L
(author)
-
Monleon, I
(author)
-
San-Jose, I
(author)
-
Arbizu, J
(author)
-
Martinez-Lage, P
(author)
-
Munuera, J
(author)
-
Ruiz, A
(author)
-
Tarraga, L
(author)
-
Boada, M
(author)
-
Sarasa, M
(author)
-
Goni, M
(author)
-
Pujadas, F
(author)
-
Villarejo, A
(author)
-
Frank, A
(author)
-
Pena-Casanova, J
(author)
-
Fernandez, M
(author)
-
Pinol, G
(author)
-
Blesa, R
(author)
-
Gil, P
(author)
-
Pascual, LF
(author)
-
Aguilar, M
(author)
-
Frisoni, GB
(author)
-
Matias-Guiu, J
(author)
-
Andreasen, N
(author)
-
Antunez, C
(author)
-
Vellas, B
(author)
-
Touchon, J
(author)
Related titles
-
In:The journal of prevention of Alzheimer's disease: SERDI6:1, s. 34-412426-02662274-5807
Internet link
Find in a library
To the university's database
- By the author/editor
-
Perez-Grijalba, ...
-
Romero, J
-
Pesini, P
-
Sarasa, L
-
Monleon, I
-
San-Jose, I
-
show more...
-
Arbizu, J
-
Martinez-Lage, P
-
Munuera, J
-
Ruiz, A
-
Tarraga, L
-
Boada, M
-
Sarasa, M
-
Goni, M
-
Pujadas, F
-
Villarejo, A
-
Frank, A
-
Pena-Casanova, J
-
Fernandez, M
-
Pinol, G
-
Blesa, R
-
Gil, P
-
Pascual, LF
-
Aguilar, M
-
Frisoni, GB
-
Matias-Guiu, J
-
Andreasen, N
-
Antunez, C
-
Vellas, B
-
Touchon, J
-
show less...
- Articles in the publication
-
The journal of p ...
- By the university
-
Karolinska Institutet