Search: onr:"swepub:oai:prod.swepub.kib.ki.se:140718307" >
Genome-wide associa...
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Ferreira, MAQIMR Berghofer Medical Research Institute
(author)
Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-04-15
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Springer Science and Business Media LLC,2019
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:140718307
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http://kipublications.ki.se/Default.aspx?queryparsed=id:140718307URI
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https://doi.org/10.1038/s41467-018-08053-5DOI
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https://lup.lub.lu.se/record/e3cc4683-efe4-47de-a091-291384242383URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. We determine the directional effect of gene expression on disease risk measured based on single and multiple eQTL. In addition, using a gene-based test of association that considers eQTL from multiple tissues, we identify seven (and four) regions with variants associated with overall (and ER-negative) breast cancer risk, which were not reported in previous GWAS. Further investigation of the function of the implicated genes in breast and immune cells may provide insights into the etiology of breast cancer.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Gamazon, ER
(author)
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Al-Ejeh, F
(author)
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Aittomaki, K
(author)
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Andrulis, IL
(author)
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Anton-Culver, H
(author)
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Arason, A
(author)
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Arndt, V
(author)
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Aronson, KJ
(author)
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Arun, BK
(author)
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Asseryanis, E
(author)
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Azzollini, J
(author)
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Balmana, J
(author)
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Barnes, DR
(author)
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Barrowdale, D
(author)
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Beckmann, MW
(author)
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Behrens, S
(author)
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Benitez, J
(author)
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Bermisheva, M
(author)
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Bialkowska, K
(author)
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Blomqvist, C
(author)
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Bogdanova, N
(author)
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Bojesen, SE
(author)
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Bolla, MK
(author)
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Borg, ÅkeLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,Skåne University Hospital(Swepub:lu)onk-abo
(author)
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Brauch, H
(author)
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Brenner, H
(author)
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Broeks, A
(author)
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Burwinkel, B
(author)
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Caldes, T
(author)
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Caligo, MA
(author)
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Campa, D
(author)
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Campbell, I
(author)
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Canzian, F
(author)
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Carter, J
(author)
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Carter, BD
(author)
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Castelao, JE
(author)
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Chang-Claude, J
(author)
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Chanock, SJ
(author)
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Christiansen, H
(author)
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Chung, WK
(author)
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Claes, KBM
(author)
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Clarke, CL
(author)
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Couch, FJ
(author)
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Cox, A
(author)
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Cross, SS
(author)
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Czene, KKarolinska Institutet
(author)
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Daly, MB
(author)
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de la Hoya, M
(author)
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Dennis, J
(author)
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Devilee, P
(author)
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Diez, O
(author)
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Dork, T
(author)
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Dunning, AM
(author)
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Dwek, M
(author)
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Eccles, DM
(author)
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Ejlertsen, B
(author)
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Ellberg, CarolinaLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-elc
(author)
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Engel, C
(author)
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Eriksson, MKarolinska Institutet
(author)
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Fasching, PA
(author)
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Fletcher, O
(author)
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Flyger, H
(author)
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Friedman, E
(author)
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Frost, D
(author)
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Gabrielson, MKarolinska Institutet
(author)
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Gago-Dominguez, M
(author)
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Ganz, PA
(author)
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Gapstur, SM
(author)
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Garber, J
(author)
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Garcia-Closas, M
(author)
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Garcia-Saenz, JA
(author)
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Gaudet, MM
(author)
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Giles, GG
(author)
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Glendon, G
(author)
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Godwin, AK
(author)
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Goldberg, MS
(author)
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Goldgar, DE
(author)
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Gonzalez-Neira, A
(author)
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Greene, MH
(author)
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Gronwald, J
(author)
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Guenel, P
(author)
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Haiman, CA
(author)
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Hall, PKarolinska Institutet
(author)
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Hamann, U
(author)
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He, WKarolinska Institutet
(author)
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Heyworth, J
(author)
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Hogervorst, FBL
(author)
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Hollestelle, A
(author)
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Hoover, RN
(author)
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Hopper, JL
(author)
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Hulick, PJ
(author)
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Humphreys, KKarolinska Institutet
(author)
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Imyanitov, EN
(author)
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Isaacs, C
(author)
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Jakimovska, M
(author)
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Jakubowska, A
(author)
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James, PA
(author)
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Janavicius, R
(author)
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Jankowitz, RC
(author)
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John, EM
(author)
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Johnson, N
(author)
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Joseph, V
(author)
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Karlan, BY
(author)
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Khusnutdinova, E
(author)
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Kiiski, J
(author)
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Ko, YD
(author)
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Jones, ME
(author)
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Konstantopoulou, I
(author)
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Kristensen, VN
(author)
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Laitman, Y
(author)
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Lambrechts, D
(author)
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Lazaro, C
(author)
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Leslie, G
(author)
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Lester, J
(author)
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Lesueur, F
(author)
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Lindstrom, S
(author)
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Long, JR
(author)
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Loud, JT
(author)
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Lubinski, J
(author)
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Makalic, E
(author)
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Mannermaa, A
(author)
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Manoochehri, M
(author)
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Margolin, SKarolinska Institutet
(author)
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Maurer, T
(author)
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Mavroudis, D
(author)
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McGuffog, L
(author)
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Meindl, A
(author)
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Menon, U
(author)
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Michailidou, K
(author)
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Miller, A
(author)
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Montagna, M
(author)
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Moreno, F
(author)
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Moserle, L
(author)
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Mulligan, AM
(author)
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Nathanson, KL
(author)
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Neuhausen, SL
(author)
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Nevanlinna, H
(author)
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Nevelsteen, I
(author)
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Nielsen, FC
(author)
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Nikitina-Zake, L
(author)
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Nussbaum, RL
(author)
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Offit, K
(author)
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Olah, E
(author)
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Olopade, O
(author)
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Olsson, HåkanLund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumörmikromiljö,Institutionen för kliniska vetenskaper, Lund,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Tumor microenvironment,Department of Clinical Sciences, Lund,Lund Melanoma Study Group,Lund University Research Groups,Skåne University Hospital(Swepub:lu)onk-hol
(author)
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Osorio, A
(author)
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Papp, J
(author)
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Park-Simon, TW
(author)
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Parsons, MT
(author)
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Pedersen, IS
(author)
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Peixoto, A
(author)
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Peterlongo, P
(author)
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Pharoah, PDP
(author)
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Plaseska-Karanfilska, D
(author)
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Poppe, B
(author)
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Presneau, N
(author)
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Radice, P
(author)
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Rantala, JKarolinska Institutet
(author)
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Rennert, G
(author)
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Risch, HA
(author)
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Saloustros, E
(author)
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Sanden, K
(author)
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Sawyer, EJ
(author)
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Schmidt, MK
(author)
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Schmutzler, RK
(author)
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Sharma, P
(author)
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Shu, XO
(author)
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Simard, J
(author)
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Singer, CF
(author)
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Soucy, P
(author)
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Southey, MC
(author)
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Spinelli, JJ
(author)
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Spurdle, AB
(author)
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Stone, J
(author)
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Swerdlow, AJ
(author)
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Tapper, WJ
(author)
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Taylor, JA
(author)
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Teixeira, MR
(author)
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Terry, MB
(author)
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Teule, A
(author)
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Thomassen, M
(author)
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Thone, K
(author)
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Thull, DL
(author)
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Tischkowitz, M
(author)
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Toland, AE
(author)
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Torres, D
(author)
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Truong, T
(author)
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Tung, N
(author)
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Vachon, CM
(author)
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van Asperen, CJ
(author)
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van den Ouweland, AMW
(author)
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van Rensburg, EJ
(author)
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Vega, A
(author)
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Viel, A
(author)
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Wang, Q
(author)
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Wappenschmidt, B
(author)
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Weitzel, JN
(author)
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Wendt, CKarolinska Institutet
(author)
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Winqvist, R
(author)
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Yang, XHR
(author)
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Yannoukakos, D
(author)
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Ziogas, A
(author)
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Kraft, P
(author)
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Antoniou, AC
(author)
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Zheng, W
(author)
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Easton, DF
(author)
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Milne, RL
(author)
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Beesley, J
(author)
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Chenevix-Trench, G
(author)
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Arnold, N
(author)
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Auber, B
(author)
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Bogdanova-Markov, N
(author)
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Borde, J
(author)
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Caliebe, A
(author)
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Ditsch, N
(author)
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Dworniczak, B
(author)
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Engert, S
(author)
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Faust, U
(author)
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Gehrig, A
(author)
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Hahnen, E
(author)
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Hauke, J
(author)
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Hentschel, J
(author)
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Herold, N
(author)
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Honisch, E
(author)
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Just, W
(author)
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Kast, K
(author)
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Larsen, M
(author)
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Lemke, J
(author)
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Nguyen, HP
(author)
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Niederacher, D
(author)
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Ott, CE
(author)
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Platzer, K
(author)
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Pohl-Rescigno, E
(author)
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Ramser, J
(author)
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Rhiem, K
(author)
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Steinemann, D
(author)
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Sutter, C
(author)
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Varon-Mateeva, R
(author)
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Wang-Gohrke, S
(author)
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Weber, BHF
(author)
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Prieur, F
(author)
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Pujol, P
(author)
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Sagne, C
(author)
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Sevenet, N
(author)
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Sobol, H
(author)
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Sokolowska, J
(author)
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Stoppa-Lyonnet, D
(author)
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Venat-Bouvet, L
(author)
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Adlard, J
(author)
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Ahmed, M
(author)
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Barwell, J
(author)
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Brady, A
(author)
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Brewer, C
(author)
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Cook, J
(author)
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Davidson, R
(author)
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Donaldson, A
(author)
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Eason, J
(author)
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Eeles, R
(author)
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Evans, DG
(author)
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Gregory, H
(author)
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Hanson, H
(author)
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Henderson, A
(author)
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Hodgson, S
(author)
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Izatt, L
(author)
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Kennedy, MJ
(author)
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Lalloo, F
(author)
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Miller, C
(author)
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Morrison, PJ
(author)
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Ong, KR
(author)
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Perkins, J
(author)
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Porteous, ME
(author)
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Rogers, MT
(author)
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Side, LE
(author)
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Snape, K
(author)
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Walker, L
(author)
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Harrington, PA
(author)
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Heemskerk-Gerritsen, BAM
(author)
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Rookus, MA
(author)
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Seynaeve, CM
(author)
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van der Baan, FH
(author)
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van der Hout, AH
(author)
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van der Kolk, LE
(author)
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van der Luijt, RB
(author)
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van Deurzen, CHM
(author)
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van Doorn, HC
(author)
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van Engelen, K
(author)
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van Hest, L
(author)
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van Os, TAM
(author)
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Verhoef, S
(author)
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Vogel, MJ
(author)
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Wijnen, JT
(author)
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Miron, A
(author)
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Kapuscinski, M
(author)
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Bane, A
(author)
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Ross, E
(author)
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Buys, SS
(author)
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Conner, TA
(author)
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Balleine, R
(author)
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Baxter, R
(author)
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Braye, S
(author)
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Carpenter, J
(author)
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Dahlstrom, J
(author)
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Forbes, J
(author)
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Lee, SC
(author)
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Marsh, D
(author)
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Morey, A
(author)
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Pathmanathan, N
(author)
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Simpson, P
(author)
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Spigelman, A
(author)
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Wilcken, N
(author)
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Yip, D
(author)
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QIMR Berghofer Medical Research InstituteBröstcancer-genetik
(creator_code:org_t)
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In:Nature communications: Springer Science and Business Media LLC10:1, s. 1741-2041-1723
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Ferreira, MA
-
Gamazon, ER
-
Al-Ejeh, F
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Aittomaki, K
-
Andrulis, IL
-
Anton-Culver, H
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show more...
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Arason, A
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Arndt, V
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Aronson, KJ
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Arun, BK
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Asseryanis, E
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Azzollini, J
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Balmana, J
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Barnes, DR
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Barrowdale, D
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Beckmann, MW
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Behrens, S
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Benitez, J
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Bermisheva, M
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Bialkowska, K
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Blomqvist, C
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Bogdanova, N
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Bojesen, SE
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Bolla, MK
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Borg, Åke
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Brauch, H
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Brenner, H
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Broeks, A
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Burwinkel, B
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Caldes, T
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Caligo, MA
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Campa, D
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Campbell, I
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Canzian, F
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Carter, J
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Carter, BD
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Castelao, JE
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Chang-Claude, J
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Chanock, SJ
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Christiansen, H
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Chung, WK
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Claes, KBM
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Clarke, CL
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Couch, FJ
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Cox, A
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Cross, SS
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Czene, K
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Daly, MB
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de la Hoya, M
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Dennis, J
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Devilee, P
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Diez, O
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Dork, T
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Dunning, AM
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Dwek, M
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Eccles, DM
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Ejlertsen, B
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Ellberg, Carolin ...
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Engel, C
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Eriksson, M
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Fasching, PA
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Fletcher, O
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Flyger, H
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Friedman, E
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Frost, D
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Gabrielson, M
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Gago-Dominguez, ...
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Ganz, PA
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Gapstur, SM
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Garber, J
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Garcia-Closas, M
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Garcia-Saenz, JA
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Gaudet, MM
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Giles, GG
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Glendon, G
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Godwin, AK
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Goldberg, MS
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Goldgar, DE
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Gonzalez-Neira, ...
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Greene, MH
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Gronwald, J
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Guenel, P
-
Haiman, CA
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Hall, P
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Hamann, U
-
He, W
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Heyworth, J
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Hogervorst, FBL
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Hollestelle, A
-
Hoover, RN
-
Hopper, JL
-
Hulick, PJ
-
Humphreys, K
-
Imyanitov, EN
-
Isaacs, C
-
Jakimovska, M
-
Jakubowska, A
-
James, PA
-
Janavicius, R
-
Jankowitz, RC
-
John, EM
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Johnson, N
-
Joseph, V
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Karlan, BY
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Khusnutdinova, E
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Kiiski, J
-
Ko, YD
-
Jones, ME
-
Konstantopoulou, ...
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Kristensen, VN
-
Laitman, Y
-
Lambrechts, D
-
Lazaro, C
-
Leslie, G
-
Lester, J
-
Lesueur, F
-
Lindstrom, S
-
Long, JR
-
Loud, JT
-
Lubinski, J
-
Makalic, E
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Mannermaa, A
-
Manoochehri, M
-
Margolin, S
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Maurer, T
-
Mavroudis, D
-
McGuffog, L
-
Meindl, A
-
Menon, U
-
Michailidou, K
-
Miller, A
-
Montagna, M
-
Moreno, F
-
Moserle, L
-
Mulligan, AM
-
Nathanson, KL
-
Neuhausen, SL
-
Nevanlinna, H
-
Nevelsteen, I
-
Nielsen, FC
-
Nikitina-Zake, L
-
Nussbaum, RL
-
Offit, K
-
Olah, E
-
Olopade, O
-
Olsson, Håkan
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Osorio, A
-
Papp, J
-
Park-Simon, TW
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Parsons, MT
-
Pedersen, IS
-
Peixoto, A
-
Peterlongo, P
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Pharoah, PDP
-
Plaseska-Karanfi ...
-
Poppe, B
-
Presneau, N
-
Radice, P
-
Rantala, J
-
Rennert, G
-
Risch, HA
-
Saloustros, E
-
Sanden, K
-
Sawyer, EJ
-
Schmidt, MK
-
Schmutzler, RK
-
Sharma, P
-
Shu, XO
-
Simard, J
-
Singer, CF
-
Soucy, P
-
Southey, MC
-
Spinelli, JJ
-
Spurdle, AB
-
Stone, J
-
Swerdlow, AJ
-
Tapper, WJ
-
Taylor, JA
-
Teixeira, MR
-
Terry, MB
-
Teule, A
-
Thomassen, M
-
Thone, K
-
Thull, DL
-
Tischkowitz, M
-
Toland, AE
-
Torres, D
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Truong, T
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Tung, N
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Vachon, CM
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van Asperen, CJ
-
van den Ouweland ...
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van Rensburg, EJ
-
Vega, A
-
Viel, A
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Wang, Q
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Wappenschmidt, B
-
Weitzel, JN
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Wendt, C
-
Winqvist, R
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Yang, XHR
-
Yannoukakos, D
-
Ziogas, A
-
Kraft, P
-
Antoniou, AC
-
Zheng, W
-
Easton, DF
-
Milne, RL
-
Beesley, J
-
Chenevix-Trench, ...
-
Arnold, N
-
Auber, B
-
Bogdanova-Markov ...
-
Borde, J
-
Caliebe, A
-
Ditsch, N
-
Dworniczak, B
-
Engert, S
-
Faust, U
-
Gehrig, A
-
Hahnen, E
-
Hauke, J
-
Hentschel, J
-
Herold, N
-
Honisch, E
-
Just, W
-
Kast, K
-
Larsen, M
-
Lemke, J
-
Nguyen, HP
-
Niederacher, D
-
Ott, CE
-
Platzer, K
-
Pohl-Rescigno, E
-
Ramser, J
-
Rhiem, K
-
Steinemann, D
-
Sutter, C
-
Varon-Mateeva, R
-
Wang-Gohrke, S
-
Weber, BHF
-
Prieur, F
-
Pujol, P
-
Sagne, C
-
Sevenet, N
-
Sobol, H
-
Sokolowska, J
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Stoppa-Lyonnet, ...
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Venat-Bouvet, L
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Adlard, J
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Ahmed, M
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Barwell, J
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Brady, A
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Brewer, C
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Cook, J
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Davidson, R
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Donaldson, A
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Eason, J
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Eeles, R
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Evans, DG
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Gregory, H
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Hanson, H
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Henderson, A
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Hodgson, S
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Izatt, L
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Kennedy, MJ
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Lalloo, F
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Miller, C
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Morrison, PJ
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Ong, KR
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Perkins, J
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Porteous, ME
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Rogers, MT
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Side, LE
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Snape, K
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Walker, L
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Harrington, PA
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Heemskerk-Gerrit ...
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Rookus, MA
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Seynaeve, CM
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van der Baan, FH
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van der Hout, AH
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van der Kolk, LE
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van der Luijt, R ...
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van Deurzen, CHM
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van Doorn, HC
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van Engelen, K
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van Hest, L
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van Os, TAM
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Verhoef, S
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Vogel, MJ
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Wijnen, JT
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Miron, A
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Kapuscinski, M
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Bane, A
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Ross, E
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Buys, SS
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Conner, TA
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Balleine, R
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Baxter, R
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Braye, S
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Carpenter, J
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Dahlstrom, J
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Forbes, J
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Lee, SC
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Marsh, D
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Morey, A
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Pathmanathan, N
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Simpson, P
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Spigelman, A
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Wilcken, N
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Yip, D
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- By the university
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Karolinska Institutet
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Lund University