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Genetic risk factor...
Genetic risk factors for pediatric-onset multiple sclerosis
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Gianfrancesco, MA (author)
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- Stridh, P (author)
- Karolinska Institutet
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Shao, XR (author)
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Rhead, B (author)
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Graves, JS (author)
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Chitnis, T (author)
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Waldman, A (author)
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Lotze, T (author)
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Schreiner, T (author)
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Belman, A (author)
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Greenberg, B (author)
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Weinstock-Guttman, B (author)
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Aaen, G (author)
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Tillema, JM (author)
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Hart, J (author)
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Caillier, S (author)
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Ness, J (author)
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Harris, Y (author)
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Rubin, J (author)
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Candee, M (author)
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Krupp, L (author)
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Gorman, M (author)
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Benson, L (author)
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Rodriguez, M (author)
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Mar, S (author)
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Kahn, I (author)
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Rose, J (author)
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Roalstad, S (author)
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Casper, TC (author)
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Shen, L (author)
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Quach, H (author)
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Quach, D (author)
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- Hillert, J (author)
- Karolinska Institutet
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- Hedstrom, A (author)
- Karolinska Institutet
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- Olsson, T (author)
- Karolinska Institutet
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- Kockum, I (author)
- Karolinska Institutet
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- Alfredsson, L (author)
- Karolinska Institutet
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Schaefer, C (author)
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Barcellos, LF (author)
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Waubant, E (author)
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(creator_code:org_t)
- 2017-10-05
- 2018
- English.
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In: Multiple sclerosis (Houndmills, Basingstoke, England). - : SAGE Publications. - 1477-0970 .- 1352-4585. ; 24:14, s. 1825-1834
- Related links:
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https://europepmc.or...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Strong evidence supports the role of both genetic and environmental factors in pediatric-onset multiple sclerosis (POMS) etiology. Objective: We comprehensively investigated the association between established major histocompatibility complex (MHC) and non-MHC adult multiple sclerosis (MS)-associated variants and susceptibility to POMS. Methods: Cases with onset <18 years ( n = 569) and controls ( n = 16,251) were included from the United States and Sweden. Adjusted logistic regression and meta-analyses were performed for individual risk variants and a weighted genetic risk score (wGRS) for non-MHC variants. Results were compared to adult MS cases ( n = 7588). Results: HLA–DRB1*15:01 was strongly associated with POMS (odds ratio (OR)meta = 2.95, p < 2.0 × 10−16). Furthermore, 28 of 104 non-MHC variants studied (23%) were associated ( p < 0.05); POMS cases carried, on average, a higher burden of these 28 variants compared to adults (ORavg = 1.24 vs 1.13, respectively), though the difference was not significant. The wGRS was strongly associated with POMS (ORmeta = 2.77, 95% confidence interval: 2.33, 3.32, p < 2.0 × 10−16) and higher, on average, when compared to adult cases. Additional class III risk variants in the MHC region associated with POMS were revealed after accounting for HLA–DRB1*15:01 and HLA–A*02. Conclusion: Pediatric and adult MS share many genetic variants suggesting similar biological processes are present. MHC variants beyond HLA–DRB1*15:01 and HLA–A*02 are also associated with POMS.
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- art (subject category)
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- By the author/editor
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Gianfrancesco, M ...
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Stridh, P
-
Shao, XR
-
Rhead, B
-
Graves, JS
-
Chitnis, T
-
show more...
-
Waldman, A
-
Lotze, T
-
Schreiner, T
-
Belman, A
-
Greenberg, B
-
Weinstock-Guttma ...
-
Aaen, G
-
Tillema, JM
-
Hart, J
-
Caillier, S
-
Ness, J
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Harris, Y
-
Rubin, J
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Candee, M
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Krupp, L
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Gorman, M
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Benson, L
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Rodriguez, M
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Mar, S
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Kahn, I
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Rose, J
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Roalstad, S
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Casper, TC
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Shen, L
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Quach, H
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Quach, D
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Hillert, J
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Hedstrom, A
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Olsson, T
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Kockum, I
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Alfredsson, L
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Schaefer, C
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Barcellos, LF
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Waubant, E
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show less...
- Articles in the publication
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Multiple scleros ...
- By the university
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Karolinska Institutet