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Community assessmen...
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
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Menden, MP (author)
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Wang, D (author)
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Mason, MJ (author)
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show more...
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Szalai, B (author)
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Bulusu, KC (author)
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Guan, YF (author)
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Yu, T (author)
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Kang, J (author)
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Jeon, M (author)
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Wolfinger, R (author)
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Nguyen, T (author)
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Zaslavskiy, M (author)
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Jang, IS (author)
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Ghazoui, Z (author)
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Ahsen, ME (author)
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Vogel, R (author)
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Neto, EC (author)
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Norman, T (author)
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Tang, EKY (author)
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Garnett, MJ (author)
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Di Veroli, GY (author)
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Fawell, S (author)
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Stolovitzky, G (author)
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Guinney, J (author)
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Dry, JR (author)
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Saez-Rodriguez, J (author)
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Abante, J (author)
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Abecassis, BS (author)
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Aben, N (author)
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Aghamirzaie, D (author)
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Aittokallio, T (author)
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Akhtari, FS (author)
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Al-lazikani, B (author)
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Alam, T (author)
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Allam, A (author)
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Allen, C (author)
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de Almeida, MP (author)
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Altarawy, D (author)
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Alves, V (author)
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Amadoz, A (author)
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Anchang, B (author)
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Antolin, AA (author)
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Ash, JR (author)
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Aznar, VR (author)
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Ba-alawi, W (author)
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Bagheri, M (author)
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Bajic, V (author)
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Ball, G (author)
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Ballester, PJ (author)
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Baptista, D (author)
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Bare, C (author)
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Bateson, M (author)
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Bender, A (author)
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Bertrand, D (author)
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Wijayawardena, B (author)
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Boroevich, KA (author)
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Bosdriesz, E (author)
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Bougouffa, S (author)
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Bounova, G (author)
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Brouwer, T (author)
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Bryant, B (author)
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Calaza, M (author)
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Calderone, A (author)
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Calza, S (author)
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Capuzzi, S (author)
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Carbonell-Caballero, J (author)
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Carlin, D (author)
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Carter, H (author)
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Castagnoli, L (author)
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Celebi, R (author)
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Cesareni, G (author)
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Chang, H (author)
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Chen, GC (author)
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Chen, HR (author)
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Chen, HY (author)
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Cheng, LJ (author)
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Chernomoretz, A (author)
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Chicco, D (author)
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Cho, KH (author)
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Cho, S (author)
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Choi, D (author)
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Choi, J (author)
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Choi, K (author)
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Choi, M (author)
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De Cock, M (author)
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Coker, E (author)
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Cortes-Ciriano, I (author)
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Cserzo, M (author)
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Cubuk, C (author)
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Curtis, C (author)
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Van Daele, D (author)
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Dang, CC (author)
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Dijkstra, T (author)
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Dopazo, J (author)
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Draghici, S (author)
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Drosou, A (author)
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Dumontier, M (author)
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Ehrhart, F (author)
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Eid, FE (author)
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ElHefnawi, M (author)
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Elmarakeby, H (author)
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van Engelen, B (author)
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Engin, HB (author)
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de Esch, I (author)
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Evelo, C (author)
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Falcao, AO (author)
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Farag, S (author)
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Fernandez-Lozano, C (author)
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Fisch, K (author)
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Flobak, A (author)
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Fornari, C (author)
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Foroushani, ABK (author)
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Fotso, DC (author)
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Fourches, D (author)
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Friend, S (author)
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Frigessi, A (author)
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Gao, F (author)
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Gao, XT (author)
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Gerold, JM (author)
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Gestraud, P (author)
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Ghosh, S (author)
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Gillberg, J (author)
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Godoy-Lorite, A (author)
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Godynyuk, L (author)
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Godzik, A (author)
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Goldenberg, A (author)
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- Gomez-Cabrero, D (author)
- Karolinska Institutet
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Gonen, M (author)
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de Graaf, C (author)
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Gray, H (author)
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Grechkin, M (author)
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Guimera, R (author)
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Guney, E (author)
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Haibe-Kains, B (author)
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Han, Y (author)
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Hase, T (author)
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He, D (author)
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He, LY (author)
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Heath, LS (author)
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Hellton, KH (author)
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Helmer-Citterich, M (author)
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Hidalgo, MR (author)
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Hidru, D (author)
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Hill, SM (author)
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Hochreiter, S (author)
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Hong, S (author)
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Hovig, E (author)
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Hsueh, YC (author)
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Hu, ZY (author)
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Huang, JK (author)
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Huang, RS (author)
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Hunyady, L (author)
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Hwang, J (author)
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Hwang, TH (author)
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Hwang, W (author)
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Hwang, Y (author)
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Isayev, O (author)
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Walk, OBD (author)
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Jack, J (author)
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Jahandideh, S (author)
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Ji, JD (author)
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Jo, Y (author)
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Kamola, PJ (author)
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Kanev, GK (author)
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Karacosta, L (author)
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Karimi, M (author)
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Kaski, S (author)
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Kazanov, M (author)
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Khamis, AM (author)
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Khan, SA (author)
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- Kiani, NA (author)
- Karolinska Institutet
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Kim, A (author)
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Kim, J (author)
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Kim, J (author)
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Kim, K (author)
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Kim, K (author)
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Kim, S (author)
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Kim, Y (author)
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Kim, Y (author)
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Kirk, PDW (author)
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Kitano, H (author)
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Klambauer, G (author)
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Knowles, D (author)
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Ko, M (author)
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Kohn-Luque, A (author)
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Kooistra, AJ (author)
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Kuenemann, MA (author)
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Kuiper, M (author)
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Kurz, C (author)
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Kwon, M (author)
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van Laarhoven, T (author)
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Laegreid, A (author)
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Lederer, S (author)
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Lee, H (author)
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Lee, J (author)
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Lee, YW (author)
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Leppaho, E (author)
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Lewis, R (author)
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Li, J (author)
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Li, L (author)
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Liley, J (author)
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Lim, WK (author)
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Lin, C (author)
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Liu, YY (author)
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Lopez, Y (author)
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Low, J (author)
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Lysenko, A (author)
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Machado, D (author)
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Madhukar, N (author)
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De Maeyer, D (author)
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Malpartida, AB (author)
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Mamitsuka, H (author)
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- Marabita, F (author)
- Karolinska Institutet
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Marchal, K (author)
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Marttinen, P (author)
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Mason, D (author)
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Mazaheri, A (author)
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Mehmood, A (author)
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Mehreen, A (author)
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Michaut, M (author)
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Miller, RA (author)
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Mitsopoulos, C (author)
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Modos, D (author)
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Van Moerbeke, M (author)
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Moo, K (author)
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Motsinger-Reif, A (author)
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Movva, R (author)
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Muraru, S (author)
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Muratov, E (author)
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Mushthofa, M (author)
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Nagarajan, N (author)
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Nakken, S (author)
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Nath, A (author)
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Neuvial, P (author)
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Newton, R (author)
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Ning, Z (author)
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De Niz, C (author)
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Oliva, B (author)
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Olsen, C (author)
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Palmeri, A (author)
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Panesar, B (author)
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Papadopoulos, S (author)
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Park, J (author)
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Park, S (author)
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Park, S (author)
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Pawitan, Y (author)
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Peluso, D (author)
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Pendyala, S (author)
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Peng, J (author)
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Perfetto, L (author)
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Pirro, S (author)
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Plevritis, S (author)
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Politi, R (author)
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Poon, H (author)
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Porta, E (author)
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Prellner, I (author)
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Preuer, K (author)
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Pujana, MA (author)
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Ramnarine, R (author)
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Reid, JE (author)
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Reyal, F (author)
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Richardson, S (author)
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Ricketts, C (author)
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Rieswijk, L (author)
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Rocha, M (author)
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Rodriguez-Gonzalvez, C (author)
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Roell, K (author)
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Rotroff, D (author)
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de Ruiter, JR (author)
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Rukawa, P (author)
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Sadacca, B (author)
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Safikhani, Z (author)
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Safitri, F (author)
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Sales-Pardo, M (author)
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Sauer, S (author)
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Schlichting, M (author)
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Seoane, JA (author)
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Serra, J (author)
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- Shang, MM (author)
- Karolinska Institutet
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Sharma, A (author)
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Sharma, H (author)
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Shen, Y (author)
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Shiga, M (author)
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Shin, M (author)
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Shkedy, Z (author)
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Shopsowitz, K (author)
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Sinai, S (author)
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Skola, D (author)
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Smirnov, P (author)
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Soerensen, IF (author)
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Soerensen, P (author)
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Song, JH (author)
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Song, SO (author)
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Soufan, O (author)
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Spitzmueller, A (author)
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Steipe, B (author)
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Suphavilai, C (author)
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Tamayo, SP (author)
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- Tamborero, D (author)
- Karolinska Institutet
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Tang, J (author)
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Tanoli, ZUR (author)
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Tarres-Deulofeu, M (author)
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- Tegner, J (author)
- Karolinska Institutet
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Thommesen, L (author)
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Tonekaboni, SAM (author)
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Tran, H (author)
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De Troyer, E (author)
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Truong, A (author)
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Tsunoda, T (author)
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Turu, G (author)
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Tzeng, GY (author)
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Verbeke, L (author)
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Videla, S (author)
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Vis, D (author)
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Voronkov, A (author)
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Votis, K (author)
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Wang, A (author)
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Wang, HQH (author)
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Wang, PW (author)
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Wang, S (author)
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Wang, W (author)
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Wang, XC (author)
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Wang, X (author)
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Wennerberg, K (author)
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Wernisch, L (author)
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Wessels, L (author)
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van Westen, GJP (author)
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Westerman, BA (author)
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White, SR (author)
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Willighagen, E (author)
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Wurdinger, T (author)
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Xie, L (author)
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Xie, SL (author)
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Xu, H (author)
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Yadav, B (author)
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Yau, C (author)
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Yeerna, H (author)
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Yin, JW (author)
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Yu, M (author)
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Yu, M (author)
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Yun, SJ (author)
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Zakharov, A (author)
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Zamichos, A (author)
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Zanin, M (author)
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Zeng, L (author)
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Zenil, H (author)
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Zhang, F (author)
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Zhang, PY (author)
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Zhang, W (author)
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Zhao, HY (author)
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Zhao, L (author)
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Zheng, WJ (author)
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Zoufir, A (author)
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Zucknick, M (author)
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(creator_code:org_t)
- 2019-06-17
- 2019
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 2674-
- Related links:
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Menden, MP
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Wang, D
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Mason, MJ
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Szalai, B
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Bulusu, KC
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Guan, YF
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show more...
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Yu, T
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Kang, J
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Jeon, M
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Wolfinger, R
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Nguyen, T
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Zaslavskiy, M
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Jang, IS
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Ghazoui, Z
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Ahsen, ME
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Vogel, R
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Neto, EC
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Norman, T
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Tang, EKY
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Garnett, MJ
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Di Veroli, GY
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Fawell, S
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Stolovitzky, G
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Guinney, J
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Dry, JR
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Saez-Rodriguez, ...
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Abante, J
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Abecassis, BS
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Aben, N
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Aghamirzaie, D
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Aittokallio, T
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Akhtari, FS
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Al-lazikani, B
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Alam, T
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Allam, A
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Allen, C
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de Almeida, MP
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Altarawy, D
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Alves, V
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Amadoz, A
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Anchang, B
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Antolin, AA
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Ash, JR
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Aznar, VR
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Ba-alawi, W
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Bagheri, M
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Bajic, V
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Ball, G
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Ballester, PJ
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Baptista, D
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Bare, C
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Bateson, M
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Bender, A
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Bertrand, D
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Wijayawardena, B
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Boroevich, KA
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Bosdriesz, E
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Bougouffa, S
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Bounova, G
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Brouwer, T
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Bryant, B
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Calaza, M
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Calderone, A
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Calza, S
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Capuzzi, S
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Carbonell-Caball ...
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Carlin, D
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Carter, H
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Castagnoli, L
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Celebi, R
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Cesareni, G
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Chang, H
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Chen, GC
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Chen, HR
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Chen, HY
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Cheng, LJ
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Chernomoretz, A
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Chicco, D
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Cho, KH
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Cho, S
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Choi, D
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Choi, J
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Choi, K
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Choi, M
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De Cock, M
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Coker, E
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Cortes-Ciriano, ...
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Cserzo, M
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Cubuk, C
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Curtis, C
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Van Daele, D
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Dang, CC
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Dijkstra, T
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Dopazo, J
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Draghici, S
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Drosou, A
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Dumontier, M
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Ehrhart, F
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Eid, FE
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ElHefnawi, M
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Elmarakeby, H
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van Engelen, B
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Engin, HB
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de Esch, I
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Evelo, C
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Falcao, AO
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Farag, S
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Fernandez-Lozano ...
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Fisch, K
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Flobak, A
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Fornari, C
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Foroushani, ABK
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Fotso, DC
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Fourches, D
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Friend, S
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Frigessi, A
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Gao, F
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Gao, XT
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Gerold, JM
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Gestraud, P
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Ghosh, S
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Gillberg, J
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Godoy-Lorite, A
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Godynyuk, L
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Godzik, A
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Goldenberg, A
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Gomez-Cabrero, D
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Gonen, M
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de Graaf, C
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Gray, H
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Grechkin, M
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Guimera, R
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Guney, E
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Haibe-Kains, B
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Han, Y
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Hase, T
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He, D
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He, LY
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Heath, LS
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Hellton, KH
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Helmer-Citterich ...
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Hidalgo, MR
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Hidru, D
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Hill, SM
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Hochreiter, S
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Hong, S
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Hovig, E
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Hsueh, YC
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Hu, ZY
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Huang, JK
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Huang, RS
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Hunyady, L
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Hwang, J
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Hwang, TH
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Hwang, W
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Hwang, Y
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Isayev, O
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Walk, OBD
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Jack, J
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Jahandideh, S
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Ji, JD
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Jo, Y
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Kamola, PJ
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Kanev, GK
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Karacosta, L
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Karimi, M
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Kaski, S
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Kazanov, M
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Khamis, AM
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Khan, SA
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Kiani, NA
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Kim, A
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Kim, J
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Kim, K
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Kim, S
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Kim, Y
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Kirk, PDW
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Kitano, H
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Klambauer, G
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Knowles, D
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Ko, M
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Kohn-Luque, A
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Kooistra, AJ
-
Kuenemann, MA
-
Kuiper, M
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Kurz, C
-
Kwon, M
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van Laarhoven, T
-
Laegreid, A
-
Lederer, S
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Lee, H
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Lee, J
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Lee, YW
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Leppaho, E
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Lewis, R
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Li, J
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Li, L
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Liley, J
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Lim, WK
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Lin, C
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Liu, YY
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Lopez, Y
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Low, J
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Lysenko, A
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Machado, D
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Madhukar, N
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De Maeyer, D
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Malpartida, AB
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Mamitsuka, H
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Marabita, F
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Marchal, K
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Marttinen, P
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Mason, D
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Mazaheri, A
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Mehmood, A
-
Mehreen, A
-
Michaut, M
-
Miller, RA
-
Mitsopoulos, C
-
Modos, D
-
Van Moerbeke, M
-
Moo, K
-
Motsinger-Reif, ...
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Movva, R
-
Muraru, S
-
Muratov, E
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Mushthofa, M
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Nagarajan, N
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Nakken, S
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Nath, A
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Neuvial, P
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Newton, R
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Ning, Z
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De Niz, C
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Oliva, B
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Olsen, C
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Palmeri, A
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Panesar, B
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Papadopoulos, S
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Park, J
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Park, S
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Pawitan, Y
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Peluso, D
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Pendyala, S
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Peng, J
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Perfetto, L
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Pirro, S
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Plevritis, S
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Politi, R
-
Poon, H
-
Porta, E
-
Prellner, I
-
Preuer, K
-
Pujana, MA
-
Ramnarine, R
-
Reid, JE
-
Reyal, F
-
Richardson, S
-
Ricketts, C
-
Rieswijk, L
-
Rocha, M
-
Rodriguez-Gonzal ...
-
Roell, K
-
Rotroff, D
-
de Ruiter, JR
-
Rukawa, P
-
Sadacca, B
-
Safikhani, Z
-
Safitri, F
-
Sales-Pardo, M
-
Sauer, S
-
Schlichting, M
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Seoane, JA
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Serra, J
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Shang, MM
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Sharma, A
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Sharma, H
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Shen, Y
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Shiga, M
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Shin, M
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Shkedy, Z
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Shopsowitz, K
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Sinai, S
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Skola, D
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Smirnov, P
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Soerensen, IF
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Soerensen, P
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Song, JH
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Song, SO
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Soufan, O
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Spitzmueller, A
-
Steipe, B
-
Suphavilai, C
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Tamayo, SP
-
Tamborero, D
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Tang, J
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Tanoli, ZUR
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Tarres-Deulofeu, ...
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Tegner, J
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Thommesen, L
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Tonekaboni, SAM
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Tran, H
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De Troyer, E
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Truong, A
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Tsunoda, T
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Turu, G
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Tzeng, GY
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Verbeke, L
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Videla, S
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Vis, D
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Voronkov, A
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Votis, K
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Wang, A
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Wang, HQH
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Wang, PW
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Wang, S
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Wang, W
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Wang, XC
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Wang, X
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Wennerberg, K
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Wernisch, L
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Wessels, L
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van Westen, GJP
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Westerman, BA
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White, SR
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Willighagen, E
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Wurdinger, T
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Xie, L
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Xie, SL
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Xu, H
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Yadav, B
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Yau, C
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Yeerna, H
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Yin, JW
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Yu, M
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Yun, SJ
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Zakharov, A
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Zamichos, A
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Zanin, M
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Zeng, L
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Zenil, H
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Zhang, F
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Zhang, PY
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Zhang, W
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Zhao, HY
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Zhao, L
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Zheng, WJ
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Zoufir, A
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Zucknick, M
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