Search: onr:"swepub:oai:prod.swepub.kib.ki.se:141338824" >
Cancer Incidence an...
Cancer Incidence and Mortality in 260,000 Nordic Twins With 30,000 Prospective Cancers
-
Skytthe, A (author)
-
Harris, JR (author)
-
- Czene, K (author)
- Karolinska Institutet
-
show more...
-
Mucci, L (author)
-
- Adami, HO (author)
- Karolinska Institutet
-
Christensen, K (author)
-
Hjelmborg, J (author)
-
Holm, NV (author)
-
Nilsen, TS (author)
-
Kaprio, J (author)
-
Pukkala, E (author)
-
show less...
-
(creator_code:org_t)
- 2019-04-25
- 2019
- English.
-
In: Twin research and human genetics : the official journal of the International Society for Twin Studies. - : Cambridge University Press (CUP). - 1832-4274. ; 22:2, s. 99-107
- Related links:
-
https://www.cambridg...
-
show more...
-
http://kipublication...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The Nordic countries have comprehensive, population-based health and medical registries linkable on individually unique personal identity codes, enabling complete long-term follow-up. The aims of this study were to describe the NorTwinCan cohort established in 2010 and assess whether the cancer mortality and incidence rates among Nordic twins are similar to those in the general population. We analyzed approximately 260,000 same-sexed twins in the nationwide twin registers in Denmark, Finland, Norway and Sweden. Cancer incidence was determined using follow-up through the national cancer registries. We estimated standardized incidence (SIR) and mortality (SMR) ratios with 95% confidence intervals (CI) across country, age, period, follow-up time, sex and zygosity. More than 30,000 malignant neoplasms have occurred among the twins through 2010. Mortality rates among twins were slightly lower than in the general population (SMR 0.96; CI 95% [0.95, 0.97]), but this depends on information about zygosity. Twins have slightly lower cancer incidence rates than the general population, with SIRs of 0.97 (95% CI [0.96, 0.99]) in men and 0.96 (95% CI [0.94, 0.97]) in women. Testicular cancer occurs more often among male twins than singletons (SIR 1.15; 95% CI [1.02, 1.30]), while cancers of the kidney (SIR 0.82; 95% CI [0.76, 0.89]), lung (SIR 0.89; 95% CI [0.85, 0.92]) and colon (SIR 0.90; 95% CI [0.87, 0.94]) occur less often in twins than in the background population. Our findings indicate that the risk of cancer among twins is so similar to the general population that cancer risk factors and estimates of heritability derived from the Nordic twin registers are generalizable to the background populations.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Skytthe, A
-
Harris, JR
-
Czene, K
-
Mucci, L
-
Adami, HO
-
Christensen, K
-
show more...
-
Hjelmborg, J
-
Holm, NV
-
Nilsen, TS
-
Kaprio, J
-
Pukkala, E
-
show less...
- Articles in the publication
-
Twin research an ...
-
Twin Research an ...
- By the university
-
Karolinska Institutet