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  • Drigo, RAE (author)

Structural basis for delta cell paracrine regulation in pancreatic islets

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-08-16
  • Springer Science and Business Media LLC,2019

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:141602611
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141602611URI
  • https://doi.org/10.1038/s41467-019-11517-xDOI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Little is known about the role of islet delta cells in regulating blood glucose homeostasis in vivo. Delta cells are important paracrine regulators of beta cell and alpha cell secretory activity, however the structural basis underlying this regulation has yet to be determined. Most delta cells are elongated and have a well-defined cell soma and a filopodia-like structure. Using in vivo optogenetics and high-speed Ca2+ imaging, we show that these filopodia are dynamic structures that contain a secretory machinery, enabling the delta cell to reach a large number of beta cells within the islet. This provides for efficient regulation of beta cell activity and is modulated by endogenous IGF-1/VEGF-A signaling. In pre-diabetes, delta cells undergo morphological changes that may be a compensation to maintain paracrine regulation of the beta cell. Our data provides an integrated picture of how delta cells can modulate beta cell activity under physiological conditions.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Jacob, S (author)
  • Garcia-Prieto, CF (author)
  • Zheng, XF (author)
  • Fukuda, M (author)
  • Nhu, HTT (author)
  • Stelmashenko, O (author)
  • Pecanha, FLM (author)
  • Rodriguez-Diaz, R (author)
  • Bushong, E (author)
  • Deerinck, T (author)
  • Phan, S (author)
  • Ali, Y (author)
  • Leibiger, IKarolinska Institutet (author)
  • Chua, MN (author)
  • Boudier, T (author)
  • Song, SH (author)
  • Graf, M (author)
  • Augustine, GJ (author)
  • Ellisman, MH (author)
  • Berggren, POKarolinska Institutet (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Nature communications: Springer Science and Business Media LLC10:1, s. 3700-2041-1723

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