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A cell fitness sele...
A cell fitness selection model for neuronal survival during development
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Wang, YQ (author)
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- Wu, HH (author)
- Karolinska Institutet
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- Fontanet, P (author)
- Karolinska Institutet
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Codeluppi, S (author)
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Akkuratova, N (author)
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- Petitpre, C (author)
- Karolinska Institutet
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- Xue-Franzen, Y (author)
- Karolinska Institutet
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Niederreither, K (author)
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Sharma, A (author)
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Da Silva, F (author)
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Comai, G (author)
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Agirman, G (author)
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Palumberi, D (author)
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- Linnarsson, S (author)
- Karolinska Institutet
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- Adameyko, I (author)
- Karolinska Institutet
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Moqrich, A (author)
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Schedl, A (author)
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La Manno, G (author)
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- Hadjab, S (author)
- Karolinska Institutet
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- Lallemend, F (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2019-09-12
- 2019
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4137-
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Abstract
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- Developmental cell death plays an important role in the construction of functional neural circuits. In vertebrates, the canonical view proposes a selection of the surviving neurons through stochastic competition for target-derived neurotrophic signals, implying an equal potential for neurons to compete. Here we show an alternative cell fitness selection of neurons that is defined by a specific neuronal heterogeneity code. Proprioceptive sensory neurons that will undergo cell death and those that will survive exhibit different molecular signatures that are regulated by retinoic acid and transcription factors, and are independent of the target and neurotrophins. These molecular features are genetically encoded, representing two distinct subgroups of neurons with contrasted functional maturation states and survival outcome. Thus, in this model, a heterogeneous code of intrinsic cell fitness in neighboring neurons provides differential competitive advantage resulting in the selection of cells with higher capacity to survive and functionally integrate into neural networks.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Wang, YQ
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Wu, HH
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Fontanet, P
-
Codeluppi, S
-
Akkuratova, N
-
Petitpre, C
-
show more...
-
Xue-Franzen, Y
-
Niederreither, K
-
Sharma, A
-
Da Silva, F
-
Comai, G
-
Agirman, G
-
Palumberi, D
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Linnarsson, S
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Adameyko, I
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Moqrich, A
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Schedl, A
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La Manno, G
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Hadjab, S
-
Lallemend, F
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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and Bioinformatics
- Articles in the publication
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Nature communica ...
- By the university
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Karolinska Institutet