Search: onr:"swepub:oai:prod.swepub.kib.ki.se:141935325" > Genetic architectur...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 10551naa a2203361 4500 | |
001 | oai:prod.swepub.kib.ki.se:141935325 | |
003 | SwePub | |
008 | 240902s2019 | |||||||||||000 ||eng| | |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1419353252 URI |
024 | 7 | a https://doi.org/10.1038/s41467-019-11954-82 DOI |
040 | a (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Tabassum, R4 aut |
245 | 1 0 | a Genetic architecture of human plasma lipidome and its link to cardiovascular disease |
264 | c 2019-09-24 | |
264 | 1 | b Springer Science and Business Media LLC,c 2019 |
520 | a Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10−8), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate<0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD. | |
700 | 1 | a Ramo, JT4 aut |
700 | 1 | a Ripatti, P4 aut |
700 | 1 | a Koskela, JT4 aut |
700 | 1 | a Kurki, M4 aut |
700 | 1 | a Karjalainen, J4 aut |
700 | 1 | a Palta, P4 aut |
700 | 1 | a Hassan, S4 aut |
700 | 1 | a Nunez-Fontarnau, J4 aut |
700 | 1 | a Kiiskinen, TTJ4 aut |
700 | 1 | a Soderlund, S4 aut |
700 | 1 | a Matikainen, N4 aut |
700 | 1 | a Gerl, MJ4 aut |
700 | 1 | a Surma, MA4 aut |
700 | 1 | a Klose, C4 aut |
700 | 1 | a Stitziel, NO4 aut |
700 | 1 | a Laivuori, H4 aut |
700 | 1 | a Havulinna, AS4 aut |
700 | 1 | a Service, SK4 aut |
700 | 1 | a Salomaa, V4 aut |
700 | 1 | a Pirinen, M4 aut |
700 | 1 | a Jauhiainen, M4 aut |
700 | 1 | a Daly, MJ4 aut |
700 | 1 | a Freimer, NB4 aut |
700 | 1 | a Palotie, A4 aut |
700 | 1 | a Taskinen, MR4 aut |
700 | 1 | a Simons, K4 aut |
700 | 1 | a Ripatti, S4 aut |
700 | 1 | a Jalanko, A4 aut |
700 | 1 | a Kaprio, J4 aut |
700 | 1 | a Donner, K4 aut |
700 | 1 | a Kaunisto, M4 aut |
700 | 1 | a Mars, N4 aut |
700 | 1 | a Dada, A4 aut |
700 | 1 | a Shcherban, A4 aut |
700 | 1 | a Ganna, A4 aut |
700 | 1 | a Lehisto, A4 aut |
700 | 1 | a Kilpelainen, E4 aut |
700 | 1 | a Brein, G4 aut |
700 | 1 | a Awaisa, G4 aut |
700 | 1 | a Harju, J4 aut |
700 | 1 | a Parr, K4 aut |
700 | 1 | a Parolo, PD4 aut |
700 | 1 | a Kajanne, R4 aut |
700 | 1 | a Lemmela, S4 aut |
700 | 1 | a Sipila, TP4 aut |
700 | 1 | a Sipila, T4 aut |
700 | 1 | a Lyhs, U4 aut |
700 | 1 | a Llorens, V4 aut |
700 | 1 | a Niiranen, T4 aut |
700 | 1 | a Kristiansson, K4 aut |
700 | 1 | a Mannikko, L4 aut |
700 | 1 | a Jimenez, MG4 aut |
700 | 1 | a Perola, M4 aut |
700 | 1 | a Wong, R4 aut |
700 | 1 | a Kilpi, T4 aut |
700 | 1 | a Hiekkalinna, T4 aut |
700 | 1 | a Jarvensivu, E4 aut |
700 | 1 | a Kaiharju, E4 aut |
700 | 1 | a Mattsson, H4 aut |
700 | 1 | a Laukkanen, M4 aut |
700 | 1 | a Laiho, P4 aut |
700 | 1 | a Lahteenmaki, S4 aut |
700 | 1 | a Sistonen, T4 aut |
700 | 1 | a Soini, S4 aut |
700 | 1 | a Ziemann, A4 aut |
700 | 1 | a Lehtonen, A4 aut |
700 | 1 | a Lertratanakul, A4 aut |
700 | 1 | a Georgantas, B4 aut |
700 | 1 | a Riley-Gillis, B4 aut |
700 | 1 | a Quarless, D4 aut |
700 | 1 | a Rahimov, F4 aut |
700 | 1 | a Heap, G4 aut |
700 | 1 | a Jacob, H4 aut |
700 | 1 | a Waring, J4 aut |
700 | 1 | a Davis, JW4 aut |
700 | 1 | a Smaoui, N4 aut |
700 | 1 | a Popovic, R4 aut |
700 | 1 | a Esmaeeli, S4 aut |
700 | 1 | a Waring, J4 aut |
700 | 1 | a Matakidou, A4 aut |
700 | 1 | a Challis, B4 aut |
700 | 1 | a Close, D4 aut |
700 | 1 | a Petrovski, S4 aut |
700 | 1 | a Karlsson, A4 aut |
700 | 1 | a Schleutker, J4 aut |
700 | 1 | a Pulkki, K4 aut |
700 | 1 | a Virolainen, P4 aut |
700 | 1 | a Kallio, L4 aut |
700 | 1 | a Mannermaa, A4 aut |
700 | 1 | a Heikkinen, S4 aut |
700 | 1 | a Kosma, VM4 aut |
700 | 1 | a Chen, CY4 aut |
700 | 1 | a Runz, H4 aut |
700 | 1 | a Liu, J4 aut |
700 | 1 | a Bronson, P4 aut |
700 | 1 | a John, S4 aut |
700 | 1 | a Landenpera, S4 aut |
700 | 1 | a Eaton, S4 aut |
700 | 1 | a Zhou, W4 aut |
700 | 1 | a Hendolin, M4 aut |
700 | 1 | a Tuovila, O4 aut |
700 | 1 | a Pakkanen, R4 aut |
700 | 1 | a Maranville, J4 aut |
700 | 1 | a Usiskin, K4 aut |
700 | 1 | a Hochfeld, M4 aut |
700 | 1 | a Plenge, R4 aut |
700 | 1 | a Yang, R4 aut |
700 | 1 | a Biswas, S4 aut |
700 | 1 | a Greenberg, S4 aut |
700 | 1 | a Laakkonen, E4 aut |
700 | 1 | a Kononen, J4 aut |
700 | 1 | a Paloneva, J4 aut |
700 | 1 | a Kujala, U4 aut |
700 | 1 | a Kuopio, T4 aut |
700 | 1 | a Laukkanen, J4 aut |
700 | 1 | a Kangasniemi, E4 aut |
700 | 1 | a Savinainen, K4 aut |
700 | 1 | a Laaksonen, R4 aut |
700 | 1 | a Arvas, M4 aut |
700 | 1 | a Ritari, J4 aut |
700 | 1 | a Partanen, J4 aut |
700 | 1 | a Hyvarinen, K4 aut |
700 | 1 | a Wahlfors, T4 aut |
700 | 1 | a Peterson, A4 aut |
700 | 1 | a Oh, D4 aut |
700 | 1 | a Chang, D4 aut |
700 | 1 | a Teng, E4 aut |
700 | 1 | a Strauss, E4 aut |
700 | 1 | a Kerchner, G4 aut |
700 | 1 | a Chen, H4 aut |
700 | 1 | a Chen, H4 aut |
700 | 1 | a Schutzman, J4 aut |
700 | 1 | a Michon, J4 aut |
700 | 1 | a Hunkapiller, J4 aut |
700 | 1 | a McCarthy, M4 aut |
700 | 1 | a Bowers, N4 aut |
700 | 1 | a Lu, T4 aut |
700 | 1 | a Bhangale, T4 aut |
700 | 1 | a Pulford, D4 aut |
700 | 1 | a Waterworth, D4 aut |
700 | 1 | a Kulkarni, D4 aut |
700 | 1 | a Xu, FL4 aut |
700 | 1 | a Betts, J4 aut |
700 | 1 | a Gordillo, JE4 aut |
700 | 1 | a Hoffman, J4 aut |
700 | 1 | a Auro, K4 aut |
700 | 1 | a McCarthy, L4 aut |
700 | 1 | a Ghosh, S4 aut |
700 | 1 | a Ehm, M4 aut |
700 | 1 | a Pitkanen, K4 aut |
700 | 1 | a Makela, T4 aut |
700 | 1 | a Loukola, A4 aut |
700 | 1 | a Joensuu, H4 aut |
700 | 1 | a Sinisalo, J4 aut |
700 | 1 | a Eklund, K4 aut |
700 | 1 | a Aaltonen, Lu Karolinska Institutet4 aut |
700 | 1 | a Farkkila, M4 aut |
700 | 1 | a Carpen, O4 aut |
700 | 1 | a Kauppi, P4 aut |
700 | 1 | a Tienari, P4 aut |
700 | 1 | a Ollila, T4 aut |
700 | 1 | a Tuomi, T4 aut |
700 | 1 | a Meretoja, T4 aut |
700 | 1 | a Pitkaranta, A4 aut |
700 | 1 | a Turunen, J4 aut |
700 | 1 | a Hannula-Jouppi, K4 aut |
700 | 1 | a Pikkarainen, S4 aut |
700 | 1 | a Seitsonen, S4 aut |
700 | 1 | a Koskinen, M4 aut |
700 | 1 | a Palomaki, A4 aut |
700 | 1 | a Rinne, J4 aut |
700 | 1 | a Metsarinne, K4 aut |
700 | 1 | a Elenius, K4 aut |
700 | 1 | a Pirila, L4 aut |
700 | 1 | a Koulu, L4 aut |
700 | 1 | a Voutilainen, M4 aut |
700 | 1 | a Juonala, M4 aut |
700 | 1 | a Peltonen, S4 aut |
700 | 1 | a Aaltonen, V4 aut |
700 | 1 | a Loboda, A4 aut |
700 | 1 | a Podgornaia, A4 aut |
700 | 1 | a Chhibber, A4 aut |
700 | 1 | a Chu, A4 aut |
700 | 1 | a Fox, C4 aut |
700 | 1 | a Diogo, D4 aut |
700 | 1 | a Holzinger, E4 aut |
700 | 1 | a Eicher, J4 aut |
700 | 1 | a Gormley, P4 aut |
700 | 1 | a Mehta, V4 aut |
700 | 1 | a Wang, XL4 aut |
700 | 1 | a Kettunen, J4 aut |
700 | 1 | a Pylkas, K4 aut |
700 | 1 | a Kalaoja, M4 aut |
700 | 1 | a Karjalainen, M4 aut |
700 | 1 | a Hinttala, R4 aut |
700 | 1 | a Kaarteenaho, R4 aut |
700 | 1 | a Vainio, S4 aut |
700 | 1 | a Mantere, T4 aut |
700 | 1 | a Remes, A4 aut |
700 | 1 | a Huhtakangas, J4 aut |
700 | 1 | a Junttila, J4 aut |
700 | 1 | a Tasanen, K4 aut |
700 | 1 | a Huilaja, L4 aut |
700 | 1 | a Luodonpaa, M4 aut |
700 | 1 | a Hautala, N4 aut |
700 | 1 | a Karihtala, P4 aut |
700 | 1 | a Kauppila, S4 aut |
700 | 1 | a Harju, T4 aut |
700 | 1 | a Blomster, T4 aut |
700 | 1 | a Soininen, H4 aut |
700 | 1 | a Harvima, I4 aut |
700 | 1 | a Pihlajamaki, J4 aut |
700 | 1 | a Kaarniranta, K4 aut |
700 | 1 | a Pelkonen, M4 aut |
700 | 1 | a Laakso, M4 aut |
700 | 1 | a Hiltunen, M4 aut |
700 | 1 | a Kiviniemi, M4 aut |
700 | 1 | a Kaipiainen-Seppanen, O4 aut |
700 | 1 | a Auvinen, P4 aut |
700 | 1 | a Kalviainen, R4 aut |
700 | 1 | a Julkunen, V4 aut |
700 | 1 | a Malarstig, A4 aut |
700 | 1 | a Hedman, A4 aut |
700 | 1 | a Marshal, C4 aut |
700 | 1 | a Whelan, C4 aut |
700 | 1 | a Lehtonen, H4 aut |
700 | 1 | a Parkkinen, J4 aut |
700 | 1 | a Linden, K4 aut |
700 | 1 | a Kalpala, K4 aut |
700 | 1 | a Miller, M4 aut |
700 | 1 | a Bing, N4 aut |
700 | 1 | a McDonough, S4 aut |
700 | 1 | a Chen, X4 aut |
700 | 1 | a Hu, XL4 aut |
700 | 1 | a Wu, Y4 aut |
700 | 1 | a Auranen, A4 aut |
700 | 1 | a Jussila, A4 aut |
700 | 1 | a Uusitalo-Jarvinen, H4 aut |
700 | 1 | a Kankaanranta, H4 aut |
700 | 1 | a Uusitalo, H4 aut |
700 | 1 | a Peltola, J4 aut |
700 | 1 | a Kahonen, M4 aut |
700 | 1 | a Isomaki, P4 aut |
700 | 1 | a Laitinen, T4 aut |
700 | 1 | a Salmi, T4 aut |
700 | 1 | a Muslin, A4 aut |
700 | 1 | a Wang, C4 aut |
700 | 1 | a Chatelain, C4 aut |
700 | 1 | a Xu, E4 aut |
700 | 1 | a Auge, F4 aut |
700 | 1 | a Call, K4 aut |
700 | 1 | a Klinger, K4 aut |
700 | 1 | a Crohns, M4 aut |
700 | 1 | a Gossel, M4 aut |
700 | 1 | a Palin, K4 aut |
700 | 1 | a Rivas, M4 aut |
700 | 1 | a Siirtola, H4 aut |
700 | 1 | a Tabuenca, JG4 aut |
710 | 2 | a Karolinska Institutet4 org |
773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 10:1, s. 4329-q 10:1<4329-x 2041-1723 |
856 | 4 | u https://www.nature.com/articles/s41467-019-11954-8.pdf |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141935325 |
856 | 4 8 | u https://doi.org/10.1038/s41467-019-11954-8 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.