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Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children
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Ferreira, DLS (author)
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- Hubel, C (author)
- Karolinska Institutet
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Herle, M (author)
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Abdulkadir, M (author)
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Loos, RJE (author)
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Bryant-Waugh, R (author)
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- Bulik, CM (author)
- Karolinska Institutet
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De Stavola, BL (author)
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Lawlor, DA (author)
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Micali, N (author)
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(creator_code:org_t)
- 2019-09-19
- 2019
- English.
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In: Metabolites. - : MDPI AG. - 2218-1989. ; 9:9
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https://www.mdpi.com...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- Eating disorders are severe illnesses characterized by both psychiatric and metabolic factors. We explored the prospective role of metabolic risk in eating disorders in a UK cohort (n = 2929 participants), measuring 158 metabolic traits in non-fasting EDTA-plasma by nuclear magnetic resonance. We associated metabolic markers at 7 years (exposure) with risk for anorexia nervosa and binge-eating disorder (outcomes) at 14, 16, and 18 years using logistic regression adjusted for maternal education, child’s sex, age, body mass index, and calorie intake at 7 years. Elevated very low-density lipoproteins, triglycerides, apolipoprotein-B/A, and monounsaturated fatty acids ratio were associated with lower odds of anorexia nervosa at age 18, while elevated high-density lipoproteins, docosahexaenoic acid and polyunsaturated fatty acids ratio, and fatty acid unsaturation were associated with higher risk for anorexia nervosa at 18 years. Elevated linoleic acid and n-6 fatty acid ratios were associated with lower odds of binge-eating disorder at 16 years, while elevated saturated fatty acid ratio was associated with higher odds of binge-eating disorder. Most associations had large confidence intervals and showed, for anorexia nervosa, different directions across time points. Overall, our results show some evidence for a role of metabolic factors in eating disorders development in adolescence.
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- art (subject category)
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- By the author/editor
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Ferreira, DLS
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Hubel, C
-
Herle, M
-
Abdulkadir, M
-
Loos, RJE
-
Bryant-Waugh, R
-
show more...
-
Bulik, CM
-
De Stavola, BL
-
Lawlor, DA
-
Micali, N
-
show less...
- Articles in the publication
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Metabolites
- By the university
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Karolinska Institutet