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- Creese, B (author)
Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease
- Article/chapterEnglish2019
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- 2019-10-22
- Springer Science and Business Media LLC,2019
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- LIBRIS-ID:oai:prod.swepub.kib.ki.se:142114739
- http://kipublications.ki.se/Default.aspx?queryparsed=id:142114739URI
- https://doi.org/10.1038/s41398-019-0592-5DOI
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- Language:English
- Summary in:English
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- Psychosis (delusions or hallucinations) in Alzheimer’s disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for schizophrenia, are commonly used in AD + P, suggesting shared mechanisms. Despite this implication, little empirical research has been conducted to examine whether there are mechanistic similarities between AD + P and schizophrenia. In this study, we tested whether polygenic risk score (PRS) for schizophrenia was associated with AD + P. Schizophrenia PRS was calculated using Psychiatric Genomics Consortium data at ten GWAS p value thresholds (PT) in 3111 AD cases from 11 cohort studies characterized for psychosis using validated, standardized tools. Association between PRS and AD + P status was tested by logistic regression in each cohort individually and the results meta-analyzed. The schizophrenia PRS was associated with AD + P at an optimum PT of 0.01. The strongest association was for delusions where a one standard deviation increase in PRS was associated with a 1.18-fold increased risk (95% CI: 1.06–1.3; p = 0.001). These new findings point towards psychosis in AD—and particularly delusions—sharing some genetic liability with schizophrenia and support a transdiagnostic view of psychotic symptoms across the lifespan.
Added entries (persons, corporate bodies, meetings, titles ...)
- Vassos, E (author)
- Bergh, S (author)
- Athanasiu, L (author)
- Johar, I (author)
- Rongve, A (author)
- Medboen, IT (author)
- Da Silva, MV (author)
- Aakhus, E (author)
- Andersen, F (author)
- Bettella, F (author)
- Braekhus, A (author)
- Djurovic, S (author)
- Paroni, G (author)
- Proitsi, P (author)
- Saltvedt, I (author)
- Seripa, D (author)
- Stordal, E (author)
- Fladby, T (author)
- Aarsland, DKarolinska Institutet (author)
- Andreassen, OA (author)
- Ballard, C (author)
- Selbaek, G (author)
- Karolinska Institutet (creator_code:org_t)
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- In:Translational psychiatry: Springer Science and Business Media LLC9:1, s. 273-2158-3188
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- Medboen, IT
- Da Silva, MV
- Aakhus, E
- Andersen, F
- Bettella, F
- Braekhus, A
- Djurovic, S
- Paroni, G
- Proitsi, P
- Saltvedt, I
- Seripa, D
- Stordal, E
- Fladby, T
- Aarsland, D
- Andreassen, OA
- Ballard, C
- Selbaek, G
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