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Muscle-selective RU...
Muscle-selective RUNX3 dependence of sensorimotor circuit development
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-01-01
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The Company of Biologists,2019
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:142258333
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http://kipublications.ki.se/Default.aspx?queryparsed=id:142258333URI
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https://doi.org/10.1242/dev.181750DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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The control of all our motor outputs requires constant monitoring by proprioceptive sensory neurons (PSNs) that convey continuous muscle sensory inputs to the spinal motor network. Yet, the molecular programs that control the establishment of this sensorimotor circuit remain largely unknown. The transcription factor RUNX3 is essential for the early steps of PSNs differentiation, making it difficult to study its role during later aspects of PSNs specification. Here, we conditionally inactivate Runx3 in PSNs after peripheral innervation and identify that RUNX3 is necessary for maintenance of cell identity of only a subgroup of PSNs, without discernable cell death. RUNX3 controls also the sensorimotor connection between PSNs and motor neurons at limb level, with muscle-by-muscle variable sensitivities to the loss of Runx3 that correlate with levels of RUNX3 in PSNs. Finally, we find that muscles and neurotrophin-3 signaling are necessary for maintenance of RUNX3 expression in PSNs. Hence, a transcriptional regulator critical for specifying a generic PSN type identity after neurogenesis, is later regulated by target muscle-derived signal to contribute to the specialized aspects of the sensorimotor connection selectivity.
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Wu, HHKarolinska Institutet
(author)
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Zelenin, PKarolinska Institutet
(author)
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Fontanet, PKarolinska Institutet
(author)
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Wanderoy, S
(author)
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Petitpre, CKarolinska Institutet
(author)
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Comai, G
(author)
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Bellardita, C
(author)
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Xue-Franzen, YKarolinska Institutet
(author)
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Huettl, RE
(author)
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Huber, AB
(author)
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Tajbakhsh, S
(author)
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Kiehn, OKarolinska Institutet
(author)
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Ernfors, PKarolinska Institutet
(author)
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Deliagina, TGKarolinska Institutet
(author)
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Lallemend, FKarolinska Institutet
(author)
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Hadjab, SKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
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In:Development (Cambridge, England): The Company of Biologists146:201477-91290950-1991
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Wang, YQ
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Wu, HH
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Zelenin, P
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Fontanet, P
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Wanderoy, S
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Petitpre, C
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show more...
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Comai, G
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Bellardita, C
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Xue-Franzen, Y
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Huettl, RE
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Huber, AB
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Tajbakhsh, S
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Kiehn, O
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Ernfors, P
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Deliagina, TG
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Lallemend, F
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Hadjab, S
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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Development (Cam ...
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Karolinska Institutet