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Comparison of smoki...
Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking
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Sikdar, S (author)
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Joehanes, R (author)
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Joubert, BR (author)
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show more...
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Xu, CJ (author)
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Vives-Usano, M (author)
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Rezwan, FI (author)
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Felix, JF (author)
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Ward, JM (author)
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Guan, WH (author)
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Richmond, RC (author)
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Brody, JA (author)
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Kupers, LK (author)
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Baiz, N (author)
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Haberg, SE (author)
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Smith, JA (author)
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Reese, SE (author)
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Aslibekyan, S (author)
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Hoyo, C (author)
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Dhingra, R (author)
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Markunas, CA (author)
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Xu, T (author)
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Reynolds, LM (author)
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Just, AC (author)
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Mandaviya, PR (author)
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Ghantous, A (author)
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Bennett, BD (author)
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Wang, TY (author)
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Bakulski, KM (author)
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- Melen, E (author)
- Karolinska Institutet
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Zhao, SS (author)
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Jin, JP (author)
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Herceg, Z (author)
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van Meurs, J (author)
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Taylor, JA (author)
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Baccarelli, AA (author)
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Murphy, SK (author)
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Liu, YM (author)
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Munthe-Kaas, MC (author)
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Deary, IJ (author)
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Nystad, W (author)
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Waldenberger, M (author)
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Annesi-Maesano, I (author)
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Conneely, K (author)
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Jaddoe, VWV (author)
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Arnett, D (author)
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Snieder, H (author)
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Kardia, SLR (author)
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Relton, CL (author)
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Ong, KK (author)
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Ewart, S (author)
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Moreno-Macias, H (author)
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Romieu, I (author)
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Sotoodehnia, N (author)
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Fornage, M (author)
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Motsinger-Reif, A (author)
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Koppelman, GH (author)
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Bustamante, M (author)
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Levy, D (author)
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London, SJ (author)
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(creator_code:org_t)
- Future Medicine Ltd, 2019
- 2019
- English.
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In: Epigenomics. - : Future Medicine Ltd. - 1750-192X .- 1750-1911. ; 11:13, s. 1487-1500
- Related links:
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https://www.futureme...
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http://kipublication...
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https://doi.org/10.2...
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Abstract
Subject headings
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- Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Sikdar, S
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Joehanes, R
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Joubert, BR
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Xu, CJ
-
Vives-Usano, M
-
Rezwan, FI
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show more...
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Felix, JF
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Ward, JM
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Guan, WH
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Richmond, RC
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Brody, JA
-
Kupers, LK
-
Baiz, N
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Haberg, SE
-
Smith, JA
-
Reese, SE
-
Aslibekyan, S
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Hoyo, C
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Dhingra, R
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Markunas, CA
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Xu, T
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Reynolds, LM
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Just, AC
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Mandaviya, PR
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Ghantous, A
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Bennett, BD
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Wang, TY
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Bakulski, KM
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Melen, E
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Zhao, SS
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Jin, JP
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Herceg, Z
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van Meurs, J
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Taylor, JA
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Baccarelli, AA
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Murphy, SK
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Liu, YM
-
Munthe-Kaas, MC
-
Deary, IJ
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Nystad, W
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Waldenberger, M
-
Annesi-Maesano, ...
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Conneely, K
-
Jaddoe, VWV
-
Arnett, D
-
Snieder, H
-
Kardia, SLR
-
Relton, CL
-
Ong, KK
-
Ewart, S
-
Moreno-Macias, H
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Romieu, I
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Sotoodehnia, N
-
Fornage, M
-
Motsinger-Reif, ...
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Koppelman, GH
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Bustamante, M
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Levy, D
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London, SJ
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show less...
- Articles in the publication
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Epigenomics
- By the university
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Karolinska Institutet