Search: onr:"swepub:oai:prod.swepub.kib.ki.se:142485353" >
Characterisation of...
Characterisation of neonatal seizures and their treatment using continuous EEG monitoring: a multicentre experience
-
Rennie, JM (author)
-
de Vries, LS (author)
-
- Blennow, M (author)
- Karolinska Institutet
-
show more...
-
Foran, A (author)
-
Shah, DK (author)
-
Livingstone, V (author)
-
van Huffelen, AC (author)
-
Mathieson, SR (author)
-
Pavlidis, E (author)
-
Weeke, LC (author)
-
Toet, MC (author)
-
- Finder, M (author)
- Karolinska Institutet
-
Pinnamaneni, RM (author)
-
Murray, DM (author)
-
Ryan, AC (author)
-
Marnane, WP (author)
-
Boylan, GB (author)
-
show less...
-
(creator_code:org_t)
- 2018-11-24
- 2019
- English.
-
In: Archives of disease in childhood. Fetal and neonatal edition. - : BMJ. - 1468-2052 .- 1359-2998. ; 104:5, s. F493-F501
- Related links:
-
https://fn.bmj.com/c...
-
show more...
-
http://kipublication...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The aim of this multicentre study was to describe detailed characteristics of electrographic seizures in a cohort of neonates monitored with multichannel continuous electroencephalography (cEEG) in 6 European centres.MethodsNeonates of at least 36 weeks of gestation who required cEEG monitoring for clinical concerns were eligible, and were enrolled prospectively over 2 years from June 2013. Additional retrospective data were available from two centres for January 2011 to February 2014. Clinical data and EEGs were reviewed by expert neurophysiologists through a central server.ResultsOf 214 neonates who had recordings suitable for analysis, EEG seizures were confirmed in 75 (35%). The most common cause was hypoxic-ischaemic encephalopathy (44/75, 59%), followed by metabolic/genetic disorders (16/75, 21%) and stroke (10/75, 13%). The median number of seizures was 24 (IQR 9–51), and the median maximum hourly seizure burden in minutes per hour (MSB) was 21 min (IQR 11–32), with 21 (28%) having status epilepticus defined as MSB>30 min/hour. MSB developed later in neonates with a metabolic/genetic disorder. Over half (112/214, 52%) of the neonates were given at least one antiepileptic drug (AED) and both overtreatment and undertreatment was evident. When EEG monitoring was ongoing, 27 neonates (19%) with no electrographic seizures received AEDs. Fourteen neonates (19%) who did have electrographic seizures during cEEG monitoring did not receive an AED.ConclusionsOur results show that even with access to cEEG monitoring, neonatal seizures are frequent, difficult to recognise and difficult to treat.Oberservation study numberNCT02160171
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Rennie, JM
-
de Vries, LS
-
Blennow, M
-
Foran, A
-
Shah, DK
-
Livingstone, V
-
show more...
-
van Huffelen, AC
-
Mathieson, SR
-
Pavlidis, E
-
Weeke, LC
-
Toet, MC
-
Finder, M
-
Pinnamaneni, RM
-
Murray, DM
-
Ryan, AC
-
Marnane, WP
-
Boylan, GB
-
show less...
- Articles in the publication
-
Archives of dise ...
- By the university
-
Karolinska Institutet