Search: onr:"swepub:oai:prod.swepub.kib.ki.se:142543869" >
Genetic correlation...
Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent
-
- Hubel, C (author)
- Karolinska Institutet
-
Gaspar, HA (author)
-
Coleman, JR (author)
-
show more...
-
Hanscombe, KB (author)
-
Purves, K (author)
-
Prokopenko, I (author)
-
Graff, M (author)
-
Ngwa, JS (author)
-
Workalemahu, T (author)
-
O'Reilly, PF (author)
-
- Bulik, CM (author)
- Karolinska Institutet
-
Breen, G (author)
-
show less...
-
(creator_code:org_t)
- 2019-12-18
- 2019
- English.
-
In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 5765-
- Related links:
-
https://www.nature.c...
-
show more...
-
http://kipublication...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Body composition is often altered in psychiatric disorders. Using genome-wide common genetic variation data, we calculate sex-specific genetic correlations amongst body fat %, fat mass, fat-free mass, physical activity, glycemic traits and 17 psychiatric traits (up to N = 217,568). Two patterns emerge: (1) anorexia nervosa, schizophrenia, obsessive-compulsive disorder, and education years are negatively genetically correlated with body fat % and fat-free mass, whereas (2) attention-deficit/hyperactivity disorder (ADHD), alcohol dependence, insomnia, and heavy smoking are positively correlated. Anorexia nervosa shows a stronger genetic correlation with body fat % in females, whereas education years is more strongly correlated with fat mass in males. Education years and ADHD show genetic overlap with childhood obesity. Mendelian randomization identifies schizophrenia, anorexia nervosa, and higher education as causal for decreased fat mass, with higher body fat % possibly being a causal risk factor for ADHD and heavy smoking. These results suggest new possibilities for targeted preventive strategies.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Hubel, C
-
Gaspar, HA
-
Coleman, JR
-
Hanscombe, KB
-
Purves, K
-
Prokopenko, I
-
show more...
-
Graff, M
-
Ngwa, JS
-
Workalemahu, T
-
O'Reilly, PF
-
Bulik, CM
-
Breen, G
-
show less...
- Articles in the publication
-
Nature communica ...
- By the university
-
Karolinska Institutet