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Genome-wide promote...
Genome-wide promoter methylation of hairy cell leukemia
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Arribas, AJ (author)
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Rinaldi, A (author)
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Chiodin, G (author)
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Kwee, I (author)
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Mensah, AA (author)
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Cascione, L (author)
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Rossi, D (author)
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Kanduri, M (author)
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- Rosenquist, R (author)
- Karolinska Institutet
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Zucca, E (author)
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Johnson, PW (author)
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Gaidano, G (author)
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Oakes, CC (author)
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Bertoni, F (author)
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Forconi, F (author)
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(creator_code:org_t)
- 2019-02-05
- 2019
- English.
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In: Blood advances. - : American Society of Hematology. - 2473-9537 .- 2473-9529. ; 3:3, s. 384-396
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https://doi.org/10.1...
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Abstract
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- Classic hairy cell leukemia (HCL) is a tumor of mature clonal B cells with unique genetic, morphologic, and phenotypic features. DNA methylation profiling has provided a new tier of investigation to gain insight into the origin and behavior of B-cell malignancies; however, the methylation profile of HCL has not been specifically investigated. DNA methylation profiling was analyzed with the Infinium HumanMethylation27 array in 41 mature B-cell tumors, including 11 HCL, 7 splenic marginal zone lymphomas (SMZLs), and chronic lymphocytic leukemia with an unmutated (n = 7) or mutated (n = 6) immunoglobulin gene heavy chain variable (IGHV) region or using IGHV3-21 (n = 10). Methylation profiles of nontumor B-cell subsets and gene expression profiling data were obtained from public databases. HCL had a methylation signature distinct from each B-cell tumor entity, including the closest entity, SMZL. Comparison with normal B-cell subsets revealed the strongest similarity with postgerminal center (GC) B cells and a clear separation from pre-GC and GC cellular programs. Comparison of the integrated analysis with post-GC B cells revealed significant hypomethylation and overexpression of BCR–TLR–NF-κB and BRAF-MAPK signaling pathways and cell adhesion, as well as hypermethylation and underexpression of cell-differentiation markers and methylated genes in cancer, suggesting regulation of the transformed hairy cells through specific components of the B-cell receptor and the BRAF signaling pathways. Our data identify a specific methylation profile of HCL, which may help to distinguish it from other mature B-cell tumors.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Arribas, AJ
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Rinaldi, A
-
Chiodin, G
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Kwee, I
-
Mensah, AA
-
Cascione, L
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show more...
-
Rossi, D
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Kanduri, M
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Rosenquist, R
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Zucca, E
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Johnson, PW
-
Gaidano, G
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Oakes, CC
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Bertoni, F
-
Forconi, F
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show less...
- Articles in the publication
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Blood advances
- By the university
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Karolinska Institutet