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Crosstalk between ROR1 and BCR pathways defines novel treatment strategies in mantle cell lymphoma

Karvonen, H (author)
University of Tampere
Chiron, D (author)
University of Nantes,Nantes University Hospital
Niininen, W (author)
University of Tampere
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Ek, Sara (author)
Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH
Jerkeman, Mats (author)
Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
Moradi, E (author)
University of Tampere
Nykter, M (author)
University of Tampere
Heckman, CA (author)
University of Helsinki
Kallioniemi, O (author)
Karolinska Institutet,University of Helsinki
Murumagi, A (author)
University of Helsinki
Ungureanu, D (author)
University of Tampere
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 (creator_code:org_t)
2017-11-09
2017
English.
In: Blood advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 1:24, s. 2257-2268
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Targeting ROR1 downregulates NF-κB p65 expression and sensitizes MCL cells to BCR- or Bcl-2–targeted drugs. Inhibition of BCR signaling by BTK-specific inhibitors such as ibrutinib impairs ROR1 levels and consecutively ROR1-targeted therapies.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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