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  • Bonomi, AIRCCS, Ctr Cardiol Monzino, Milan, Italy (author)

Analysis of the genetic variants associated with circulating levels of sgp130. Results from the IMPROVE study

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-01-14
  • Springer Science and Business Media LLC,2020

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:142789513
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:142789513URI
  • https://doi.org/10.1038/s41435-019-0090-zDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-425661URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The genes regulating circulating levels of soluble gp130 (sgp130), the antagonist of the inflammatory response in atherosclerosis driven by interleukin 6, are largely unknown. Aims of the present study were to identify genetic loci associated with circulating sgp130 and to explore the potential association between variants associated with sgp130 and markers of subclinical atherosclerosis. The study is based on IMPROVE (n = 3703), a cardiovascular multicentre study designed to investigate the determinants of carotid intima media thickness, a measure of subclinical atherosclerosis. Genomic DNA was genotyped by the CardioMetaboChip and ImmunoChip. About 360,842 SNPs were tested for association with log-transformed sgp130, using linear regression adjusted for age, gender, and population stratification using PLINK v1.07. A p value of 1 × 10−5 was chosen as threshold for significance value. In an exploratory analysis, SNPs associated with sgp130 were tested for association with c-IMT measures. We identified two SNPs significantly associated with sgp130 levels and 24 showing suggestive association with sgp130 levels. One SNP (rs17688225) on chromosome 14 was positively associated with sgp130 serum levels (β = 0.03 SE = 0.007, p = 4.77 × 10−5) and inversely associated with c-IMT (c-IMTmean–maxβ = −0.001 SE = 0.005, p = 0.0342). Our data indicate that multiple loci regulate sgp130 levels and suggest a possible common pathway between sgp130 and c-IMT measures.

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  • Veglia, FIRCCS, Ctr Cardiol Monzino, Milan, Italy (author)
  • Baldassarre, DIRCCS, Ctr Cardiol Monzino, Milan, Italy; Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy (author)
  • Strawbridge, RJKarolinska Institutet,Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland; Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden (author)
  • Golabkesh, ZKarolinska Institutet,Karolinska Inst, Inst Environm Med, Unit Translat Epidemiol, Stockholm, Sweden (author)
  • Sennblad, BengtUppsala universitet,Science for Life Laboratory, SciLifeLab(Swepub:uu)bengtsb (author)
  • Leander, KKarolinska Institutet,Karolinska Inst, IMM, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden (author)
  • Smit, AJUniv Med Ctr Groningen, Dept Med, Groningen, Netherlands; Univ Groningen, Groningen, Netherlands (author)
  • Giral, PGrp Hosp Pitie Salpetriere, AP HP, Unites Prevent Cardiovasc, Serv Endocrinol Metab, Paris, France (author)
  • Humphries, SEUCL, Ctr Cardiovasc Genet, London, England (author)
  • Tremoli, EIRCCS, Ctr Cardiol Monzino, Milan, Italy (author)
  • Hamsten, AKarolinska Institutet,Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden (author)
  • de Faire, UKarolinska Institutet,Karolinska Inst, IMM, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden (author)
  • Gigante, BKarolinska Institutet,Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden (author)
  • Sirtori, CR (author)
  • Castelnuovo, S (author)
  • Calabresi, L (author)
  • Amato, M (author)
  • Frigerio, B (author)
  • Ravani, A (author)
  • Sansaro, D (author)
  • Coggi, D (author)
  • Tedesco, CC (author)
  • Eriksson, PKarolinska Institutet (author)
  • Silveira, AKarolinska Institutet (author)
  • Laguzzi, FKarolinska Institutet (author)
  • Cooper, J (author)
  • Acharya, J (author)
  • Huttunen, K (author)
  • Rauramaa, E (author)
  • Pekkarinen, H (author)
  • Penttila, IM (author)
  • Torronen, J (author)
  • Rauramaa, R (author)
  • Van Gessel, AI (author)
  • Van Roon, AM (author)
  • Teune, GC (author)
  • Kuipers, WD (author)
  • Bruin, M (author)
  • Nicolai, A (author)
  • Haarsma-Jorritsma, P (author)
  • Mulder, DJ (author)
  • Bilo, HJG (author)
  • Smeets, GH (author)
  • Beaudeux, JL (author)
  • Kahn, JF (author)
  • Carreau, V (author)
  • Kontush, A (author)
  • Karppi, J (author)
  • Nurmi, T (author)
  • Nyyssonen, K (author)
  • Salonen, R (author)
  • Tuomainen, TP (author)
  • Tuomainen, J (author)
  • Kauhanen, J (author)
  • Kurl, S (author)
  • Vaudo, G (author)
  • Alaeddin, A (author)
  • Siepi, D (author)
  • Lupattelli, G (author)
  • Mannarino, E (author)
  • IRCCS, Ctr Cardiol Monzino, Milan, ItalyIRCCS, Ctr Cardiol Monzino, Milan, Italy; Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy (creator_code:org_t)

Related titles

  • In:Genes and immunity: Springer Science and Business Media LLC21:2, s. 100-1081476-54701466-4879

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