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Profiling of the pl...
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Egerstedt, AnnaLund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups
(author)
Profiling of the plasma proteome across different stages of human heart failure
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-12-20
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Springer Science and Business Media LLC,2019
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:142842841
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http://kipublications.ki.se/Default.aspx?queryparsed=id:142842841URI
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https://doi.org/10.1038/s41467-019-13306-yDOI
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https://lup.lub.lu.se/record/5939f427-03cb-4d11-8476-76b515273cd2URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may provide pathophysiological insights and identify therapeutic targets. Here we report application of aptamer-based proteomics to identify proteins associated with prospective HF incidence in a population-based cohort, implicating modulation of immunological, complement, coagulation, natriuretic and matrix remodeling pathways up to two decades prior to overt disease onset. We observe further divergence of these proteins from the general population in advanced HF, and regression after heart transplantation. By leveraging coronary sinus samples and transcriptomic tools, we describe likely cardiac and specific cellular origins for several of the proteins, including Nt-proBNP, thrombospondin-2, interleukin-18 receptor, gelsolin, and activated C5. Our findings provide a broad perspective on both cardiac and systemic factors associated with HF development.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Berntsson, JohnLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)med-jhb
(author)
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Smith, Maya LandenhedLund University,Lunds universitet,Artificiell intelligens och thoraxkirurgisk vetenskap (AICTS),Forskargrupper vid Lunds universitet,Artificial Intelligence in CardioThoracic Sciences (AICTS),Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-myl
(author)
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Gidlöf, OlofLund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)med-ogf
(author)
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Nilsson, RKarolinska Institute,Karolinska University Hospital
(author)
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Benson, MBeth Israel Deaconess Medical Center,Harvard University
(author)
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Wells, QSVanderbilt University,Beth Israel Deaconess Medical Center,Harvard University
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Celik, SelviLund University,Lunds universitet,Cardiovascular Epigenetics,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)med-slc
(author)
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Lejonberg, CarlLund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)ca2605le
(author)
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Farrell, LHarvard University,Beth Israel Deaconess Medical Center
(author)
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Sinha, S
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Shen, DXBeth Israel Deaconess Medical Center,Harvard University
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Lundgren, JakobLund University,Lunds universitet,Lund Hemodynamic Lab,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-jle
(author)
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Rådegran, GöranLund University,Lunds universitet,Lund Hemodynamic Lab,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-grd
(author)
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Ngo, DBeth Israel Deaconess Medical Center,Harvard University
(author)
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Engström, GunnarLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen
(author)
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Yang, QBoston University
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Wang, TJVanderbilt University
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Gerszten, REHarvard University,Beth Israel Deaconess Medical Center,Broad Institute
(author)
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Smith, J. GustavLund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Broad Institute,Skåne University Hospital(Swepub:lu)med-gvs
(author)
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Molecular Epidemiology and CardiologyForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Nature communications: Springer Science and Business Media LLC10:1, s. 5830-2041-1723
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- By the author/editor
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Egerstedt, Anna
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Berntsson, John
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Smith, Maya Land ...
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Gidlöf, Olof
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Nilsson, R
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Benson, M
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show more...
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Wells, QS
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Celik, Selvi
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Lejonberg, Carl
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Farrell, L
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Sinha, S
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Shen, DX
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Lundgren, Jakob
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Rådegran, Göran
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Ngo, D
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Engström, Gunnar
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Yang, Q
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Wang, TJ
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Gerszten, RE
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Smith, J. Gustav
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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Nature communica ...
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Karolinska Institutet
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Lund University