SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:prod.swepub.kib.ki.se:142842841"
 

Search: onr:"swepub:oai:prod.swepub.kib.ki.se:142842841" > Profiling of the pl...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Egerstedt, AnnaLund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups (author)

Profiling of the plasma proteome across different stages of human heart failure

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-12-20
  • Springer Science and Business Media LLC,2019

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:142842841
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:142842841URI
  • https://doi.org/10.1038/s41467-019-13306-yDOI
  • https://lup.lub.lu.se/record/5939f427-03cb-4d11-8476-76b515273cd2URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may provide pathophysiological insights and identify therapeutic targets. Here we report application of aptamer-based proteomics to identify proteins associated with prospective HF incidence in a population-based cohort, implicating modulation of immunological, complement, coagulation, natriuretic and matrix remodeling pathways up to two decades prior to overt disease onset. We observe further divergence of these proteins from the general population in advanced HF, and regression after heart transplantation. By leveraging coronary sinus samples and transcriptomic tools, we describe likely cardiac and specific cellular origins for several of the proteins, including Nt-proBNP, thrombospondin-2, interleukin-18 receptor, gelsolin, and activated C5. Our findings provide a broad perspective on both cardiac and systemic factors associated with HF development.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Berntsson, JohnLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)med-jhb (author)
  • Smith, Maya LandenhedLund University,Lunds universitet,Artificiell intelligens och thoraxkirurgisk vetenskap (AICTS),Forskargrupper vid Lunds universitet,Artificial Intelligence in CardioThoracic Sciences (AICTS),Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-myl (author)
  • Gidlöf, OlofLund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)med-ogf (author)
  • Nilsson, RKarolinska Institute,Karolinska University Hospital (author)
  • Benson, MBeth Israel Deaconess Medical Center,Harvard University (author)
  • Wells, QSVanderbilt University,Beth Israel Deaconess Medical Center,Harvard University (author)
  • Celik, SelviLund University,Lunds universitet,Cardiovascular Epigenetics,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)med-slc (author)
  • Lejonberg, CarlLund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)ca2605le (author)
  • Farrell, LHarvard University,Beth Israel Deaconess Medical Center (author)
  • Sinha, S (author)
  • Shen, DXBeth Israel Deaconess Medical Center,Harvard University (author)
  • Lundgren, JakobLund University,Lunds universitet,Lund Hemodynamic Lab,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-jle (author)
  • Rådegran, GöranLund University,Lunds universitet,Lund Hemodynamic Lab,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-grd (author)
  • Ngo, DBeth Israel Deaconess Medical Center,Harvard University (author)
  • Engström, GunnarLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen (author)
  • Yang, QBoston University (author)
  • Wang, TJVanderbilt University (author)
  • Gerszten, REHarvard University,Beth Israel Deaconess Medical Center,Broad Institute (author)
  • Smith, J. GustavLund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Broad Institute,Skåne University Hospital(Swepub:lu)med-gvs (author)
  • Molecular Epidemiology and CardiologyForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Nature communications: Springer Science and Business Media LLC10:1, s. 5830-2041-1723

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view