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Butler enables rapid cloud-based analysis of thousands of human genomes

Yakneen, S (author)
European Molecular Biology Laboratory Heidelberg
Waszak, SM (author)
European Molecular Biology Laboratory Heidelberg
Gertz, M (author)
Heidelberg University
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Korbel, JO (author)
European Molecular Biology Laboratory Heidelberg
Aminou, B (author)
Bartolome, J (author)
Boroevich, KA (author)
Boyce, R (author)
Brooks, AN (author)
Buchanan, A (author)
Buchhalter, I (author)
Butler, AP (author)
Byrne, NJ (author)
Cafferkey, A (author)
Campbell, PJ (author)
Chen, ZH (author)
Cho, S (author)
Choi, W (author)
Clapham, P (author)
Davis-Dusenbery, BN (author)
De La Vega, FM (author)
Demeulemeester, J (author)
Dow, MT (author)
Dursi, LJ (author)
Eils, J (author)
Eils, R (author)
Ellrott, K (author)
Farcas, C (author)
Favero, F (author)
Fayzullaev, N (author)
Ferretti, V (author)
Flicek, P (author)
Fonseca, NA (author)
Gelpi, JL (author)
Getz, G (author)
Gibson, B (author)
Grossman, RL (author)
Harismendy, O (author)
Heath, AP (author)
Heinold, MC (author)
Hess, JM (author)
Hofmann, O (author)
Hong, JH (author)
Hudson, TJ (author)
Hutter, B (author)
Hutter, CM (author)
Hubschmann, D (author)
Imoto, S (author)
Ivkovic, S (author)
Jeon, SH (author)
Jiao, W (author)
Jung, J (author)
Kabbe, R (author)
Kahles, A (author)
Kerssemakers, JNA (author)
Kim, HL (author)
Kim, H (author)
Kim, J (author)
Kim, Y (author)
Kleinheinz, K (author)
Koscher, M (author)
Koures, A (author)
Kovacevic, M (author)
Lawerenz, C (author)
Leshchiner, I (author)
Liu, J (author)
Livitz, D (author)
Mihaiescu, GL (author)
Mijalkovic, S (author)
Lazic, AM (author)
Miyano, S (author)
Miyoshi, N (author)
Nahal-Bose, HK (author)
Nakagawa, H (author)
Nastic, M (author)
Staaf, Johan (author)
Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund
Nicholson, J (author)
O'Connor, BD (author)
Ocana, D (author)
Ohi, K (author)
Ohno-Machado, L (author)
Omberg, L (author)
Ouellette, BFF (author)
Paramasivam, N (author)
Perry, MD (author)
Pihl, TD (author)
Prinz, M (author)
Puiggros, M (author)
Radovic, P (author)
Raine, KM (author)
Rheinbay, E (author)
Rosenberg, M (author)
Royo, R (author)
Ratsch, G (author)
Saksena, G (author)
Schlesner, M (author)
Shorser, SI (author)
Short, C (author)
Sofia, HJ (author)
Spring, J (author)
Stein, LD (author)
Struck, AJ (author)
Tiao, G (author)
Tijanic, N (author)
Torrents, D (author)
Van Loo, P (author)
Vazquez, M (author)
Vicente, D (author)
Wala, JA (author)
Wang, ZN (author)
Weischenfeldt, J (author)
Werner, J (author)
Williams, A (author)
Woo, Y (author)
Wright, AJ (author)
Xiang, Q (author)
Yang, LM (author)
Yuen, D (author)
Yung, CK (author)
Zhang, JJ (author)
Borg, Åke (creator_code:cre_t)
Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
Ringnér, Markus (creator_code:cre_t)
Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science
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 (creator_code:org_t)
2020-02-05
2020
English.
In: Nature biotechnology. - : Springer Science and Business Media LLC. - 1546-1696 .- 1087-0156. ; 38:3, s. 288-
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.

Subject headings

NATURVETENSKAP  -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
NATURAL SCIENCES  -- Computer and Information Sciences -- Bioinformatics (hsv//eng)

Keyword

Cloud Computing
Computational Biology/methods
Genome, Human
Humans
Neoplasms/genetics
Software

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Yakneen, S
Waszak, SM
Gertz, M
Korbel, JO
Aminou, B
Bartolome, J
show more...
Boroevich, KA
Boyce, R
Brooks, AN
Buchanan, A
Buchhalter, I
Butler, AP
Byrne, NJ
Cafferkey, A
Campbell, PJ
Chen, ZH
Cho, S
Choi, W
Clapham, P
Davis-Dusenbery, ...
De La Vega, FM
Demeulemeester, ...
Dow, MT
Dursi, LJ
Eils, J
Eils, R
Ellrott, K
Farcas, C
Favero, F
Fayzullaev, N
Ferretti, V
Flicek, P
Fonseca, NA
Gelpi, JL
Getz, G
Gibson, B
Grossman, RL
Harismendy, O
Heath, AP
Heinold, MC
Hess, JM
Hofmann, O
Hong, JH
Hudson, TJ
Hutter, B
Hutter, CM
Hubschmann, D
Imoto, S
Ivkovic, S
Jeon, SH
Jiao, W
Jung, J
Kabbe, R
Kahles, A
Kerssemakers, JN ...
Kim, HL
Kim, H
Kim, J
Kim, Y
Kleinheinz, K
Koscher, M
Koures, A
Kovacevic, M
Lawerenz, C
Leshchiner, I
Liu, J
Livitz, D
Mihaiescu, GL
Mijalkovic, S
Lazic, AM
Miyano, S
Miyoshi, N
Nahal-Bose, HK
Nakagawa, H
Nastic, M
Staaf, Johan
Nicholson, J
O'Connor, BD
Ocana, D
Ohi, K
Ohno-Machado, L
Omberg, L
Ouellette, BFF
Paramasivam, N
Perry, MD
Pihl, TD
Prinz, M
Puiggros, M
Radovic, P
Raine, KM
Rheinbay, E
Rosenberg, M
Royo, R
Ratsch, G
Saksena, G
Schlesner, M
Shorser, SI
Short, C
Sofia, HJ
Spring, J
Stein, LD
Struck, AJ
Tiao, G
Tijanic, N
Torrents, D
Van Loo, P
Vazquez, M
Vicente, D
Wala, JA
Wang, ZN
Weischenfeldt, J
Werner, J
Williams, A
Woo, Y
Wright, AJ
Xiang, Q
Yang, LM
Yuen, D
Yung, CK
Zhang, JJ
Borg, Åke
Ringnér, Markus
show less...
About the subject
NATURAL SCIENCES
NATURAL SCIENCES
and Computer and Inf ...
and Bioinformatics
Articles in the publication
Nature biotechno ...
By the university
Karolinska Institutet
Lund University

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