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Aortic Valve Calciu...
Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease
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- Dai, L (author)
- Karolinska Institutet
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- Plunde, O (author)
- Karolinska Institutet
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- Qureshi, AR (author)
- Karolinska Institutet
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- Lindholm, B (author)
- Karolinska Institutet
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- Brismar, TB (author)
- Karolinska Institutet
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Schurgers, LJ (author)
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Soderberg, M (author)
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- Ripsweden, J (author)
- Karolinska Institutet
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- Back, M (author)
- Karolinska Institutet
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- Stenvinkel, P (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-02-24
- 2020
- English.
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In: Journal of clinical medicine. - : MDPI AG. - 2077-0383. ; 9:2
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https://doi.org/10.3...
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Abstract
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- Background: Aortic valve calcium (AVC) and coronary artery calcium (CAC) are common complications in end-stage renal disease (ESRD). We investigated the prognostic significance of overlapping presence of AVC and CAC, and whether AVC was associated with all-cause mortality independent of the presence of CAC in ESRD. Methods: 259 ESRD patients (median age 55 years, 67% males) undergoing cardiac computed tomography were included. Framingham risk score (FRS), presence of cardiovascular disease (CVD), statin use, nutritional status and other relevant laboratory data were determined at baseline. During follow-up for median 36 months, 44 patients died, and 68 patients underwent renal transplantation. Results: The baseline overlap presence of AVC and CAC was 37%. Multivariate regression analysis showed that FRS (odds ratio (OR) 2.25; 95% confidence interval (95% CI), 1.43–3.55) and CAC score (OR (95% CI), 2.18 (1.34–3.59)) were independent determinants of AVC. In competing-risk regression models adjusted for presence of CAC, inflammation, nutritional status, CVD, FRS and statin use, AVC remained independently associated with all-cause mortality (sub-hazard ratio (95% CI), 2.57 (1.20–5.51)). Conclusions: The overlap of AVC and CAC was 37% in this ESRD cohort. AVC was associated with increased all-cause mortality independent of presence of CAC, traditional risk factors and inflammation.
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- ref (subject category)
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- By the author/editor
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Dai, L
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Plunde, O
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Qureshi, AR
-
Lindholm, B
-
Brismar, TB
-
Schurgers, LJ
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show more...
-
Soderberg, M
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Ripsweden, J
-
Back, M
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Stenvinkel, P
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show less...
- Articles in the publication
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Journal of clini ...
- By the university
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Karolinska Institutet