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Methylation deficie...
Methylation deficiency disrupts biological rhythms from bacteria to humans
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-05-06
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Springer Science and Business Media LLC,2020
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:143639759
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143639759URI
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https://doi.org/10.1038/s42003-020-0942-0DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation of nuclei acids and proteins, regulating all aspects of cellular physiology. We have previously shown that methyl cycle inhibition in mammals strongly affects circadian rhythms. Since the methyl cycle and circadian clocks have evolved early during evolution and operate in organisms across the tree of life, we sought to determine whether the link between the two is also conserved. Here, we show that methyl cycle inhibition affects biological rhythms in species ranging from unicellular algae to humans, separated by more than 1 billion years of evolution. In contrast, the cyanobacterial clock is resistant to methyl cycle inhibition, although we demonstrate that methylations themselves regulate circadian rhythms in this organism. Mammalian cells with a rewired bacteria-like methyl cycle are protected, like cyanobacteria, from methyl cycle inhibition, providing interesting new possibilities for the treatment of methylation deficiencies.
Added entries (persons, corporate bodies, meetings, titles ...)
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Ye, SQ
(author)
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Rakers, C
(author)
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Kaneko, K
(author)
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Fukumoto, K
(author)
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Yamano, M
(author)
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Versteven, M
(author)
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Grunewald, E
(author)
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Cargill, SJ
(author)
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Tamai, TK
(author)
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Xu, Y
(author)
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Jabbur, ML
(author)
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Kojima, R
(author)
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Lamberti, ML
(author)
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Yoshioka-Kobayashi, K
(author)
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Whitmore, D
(author)
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Tammam, S
(author)
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Howell, PL
(author)
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Kageyama, R
(author)
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Matsuo, T
(author)
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Stanewsky, R
(author)
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Golombek, DA
(author)
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Johnson, CH
(author)
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Kakeya, H
(author)
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van Ooijen, G
(author)
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Okamura, H
(author)
Related titles
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In:Communications biology: Springer Science and Business Media LLC3:1, s. 211-2399-3642
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- By the author/editor
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Fustin, JM
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Ye, SQ
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Rakers, C
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Kaneko, K
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Fukumoto, K
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Yamano, M
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show more...
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Versteven, M
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Grunewald, E
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Cargill, SJ
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Tamai, TK
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Xu, Y
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Jabbur, ML
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Kojima, R
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Lamberti, ML
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Yoshioka-Kobayas ...
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Whitmore, D
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Tammam, S
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Howell, PL
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Kageyama, R
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Matsuo, T
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Stanewsky, R
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Golombek, DA
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Johnson, CH
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Kakeya, H
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van Ooijen, G
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Okamura, H
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- Articles in the publication
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Communications b ...
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Karolinska Institutet