onr:"swepub:oai:prod.swepub.kib.ki.se:143904860"
Search: onr:"swepub:oai:prod.swepub.kib.ki.se:143904860" > In Vivo Visual Scre...
- 1 of 1
- Previous record
- Next record
- To hitlist
In Vivo Visual Screen for Dopaminergic Rab ↔ LRRK2-G2019S Interactions in Drosophila Discriminates Rab10 from Rab3
- Petridi, S (author)
- Middleton, CA (author)
- Ugbode, C (author)
- show more...
- Fellgett, A (author)
- Elliott, CJH (author)
- show less...
- (creator_code:org_t)
- 2020-06-01
- 2020
- English.
- In: G3 (Bethesda, Md.). - : Oxford University Press (OUP). - 2160-1836. ; 10:6, s. 1903-1914
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- LRRK2 mutations cause Parkinson’s, but the molecular link from increased kinase activity to pathological neurodegeneration remains undetermined. Previous in vitro assays indicate that LRRK2 substrates include at least 8 Rab GTPases. We have now examined this hypothesis in vivo in a functional, electroretinogram screen, expressing each Rab with/without LRRK2-G2019S in selected Drosophila dopaminergic neurons. Our screen discriminated Rab10 from Rab3. The strongest Rab/LRRK2-G2019S interaction is with Rab10; the weakest with Rab3. Rab10 is expressed in a different set of dopaminergic neurons from Rab3. Thus, anatomical and physiological patterns of Rab10 are related. We conclude that Rab10 is a valid substrate of LRRK2 in dopaminergic neurons in vivo. We propose that variations in Rab expression contribute to differences in the rate of neurodegeneration recorded in different dopaminergic nuclei in Parkinson’s.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- G3 (Bethesda, Md.) (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Petridi, S
- Middleton, CA
- Ugbode, C
- Fellgett, A
- Covill, L
- Elliott, CJH
- Articles in the publication
- G3 (Bethesda, Md ...
- By the university
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
