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HIV-1 Sub-Subtype A...
HIV-1 Sub-Subtype A6: Settings for Normalised Identification and Molecular Epidemiology in the Southern Federal District, Russia
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Schlosser, M (författare)
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Kartashev, VV (författare)
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Mikkola, VH (författare)
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Shemshura, A (författare)
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Saukhat, S (författare)
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Kolpakov, D (författare)
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Suladze, A (författare)
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Tverdokhlebova, T (författare)
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Hutt, K (författare)
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Heger, E (författare)
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Knops, E (författare)
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Bohm, M (författare)
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Di Cristanziano, V (författare)
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Kaiser, R (författare)
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- Sonnerborg, A (författare)
- Karolinska Institutet
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Zazzi, M (författare)
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Bobkova, M (författare)
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Sierra, S (författare)
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(creator_code:org_t)
- 2020-04-22
- 2020
- Engelska.
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Ingår i: Viruses. - : MDPI AG. - 1999-4915. ; 12:4
- Relaterad länk:
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https://www.mdpi.com...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
Ämnesord
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- Russia has one of the largest and fastest growing HIV epidemics. However, epidemiological data are scarce. Sub-subtype A6 is most prevalent in Russia but its identification is challenging. We analysed protease/reverse transcriptase-, integrase-sequences, and epidemiological data from 303 patients to develop a methodology for the systematisation of A6 identification and to describe the HIV epidemiology in the Russian Southern Federal District. Drug consumption (32.0%) and heterosexual contact (27.1%) were the major reported transmission risks. This study successfully established the settings for systematic identification of A6 samples. Low frequency of subtype B (3.3%) and large prevalence of sub-subtype A6 (69.6%) and subtype G (23.4%) were detected. Transmitted PI- (8.8%) and NRTI-resistance (6.4%) were detected in therapy-naive patients. In therapy-experienced patients, 17.3% of the isolates showed resistance to PIs, 50.0% to NRTI, 39.2% to NNRTIs, and 9.5% to INSTIs. Multiresistance was identified in 52 isolates, 40 corresponding to two-class resistance and seven to three-class resistance. Two resistance-associated-mutations significantly associated to sub-subtype A6 samples: A62VRT and G190SRT. This study establishes the conditions for a systematic annotation of sub-subtype A6 to normalise epidemiological studies. Accurate knowledge on South Russian epidemiology will allow for the development of efficient regional frameworks for HIV-1 infection management.
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- art (ämneskategori)
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Viruses
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- Av författaren/redakt...
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Schlosser, M
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Kartashev, VV
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Mikkola, VH
-
Shemshura, A
-
Saukhat, S
-
Kolpakov, D
-
visa fler...
-
Suladze, A
-
Tverdokhlebova, ...
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Hutt, K
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Heger, E
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Knops, E
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Bohm, M
-
Di Cristanziano, ...
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Kaiser, R
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Sonnerborg, A
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Zazzi, M
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Bobkova, M
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Sierra, S
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visa färre...
- Artiklar i publikationen
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Viruses
- Av lärosätet
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Karolinska Institutet