Search: onr:"swepub:oai:prod.swepub.kib.ki.se:144060184" >
Neurogenesis of med...
Neurogenesis of medium spiny neurons in the nucleus accumbens continues into adulthood and is enhanced by pathological pain
-
Garcia-Gonzalez, D (author)
-
Dumitru, I (author)
-
Zuccotti, A (author)
-
show more...
-
Yen, TY (author)
-
Herranz-Perez, V (author)
-
Tan, LL (author)
-
Neitz, A (author)
-
Garcia-Verdugo, JM (author)
-
Kuner, R (author)
-
Alfonso, J (author)
-
Monyer, H (author)
-
show less...
- 2020-07-01
- 2021
- English.
-
In: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 26:9, s. 4616-4632
- Related links:
-
https://doi.org/10.1...
-
show more...
-
http://kipublication...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- In mammals, most adult neural stem cells (NSCs) are located in the ventricular–subventricular zone (V-SVZ) along the wall of the lateral ventricles and they are the source of olfactory bulb interneurons. Adult NSCs exhibit an apico-basal polarity; they harbor a short apical process and a long basal process, reminiscent of radial glia morphology. In the adult mouse brain, we detected extremely long radial glia-like fibers that originate from the anterior–ventral V-SVZ and that are directed to the ventral striatum. Interestingly, a fraction of adult V-SVZ-derived neuroblasts dispersed in close association with the radial glia-like fibers in the nucleus accumbens (NAc). Using several in vivo mouse models, we show that newborn neurons integrate into preexisting circuits in the NAc where they mature as medium spiny neurons (MSNs), i.e., a type of projection neurons formerly believed to be generated only during embryonic development. Moreover, we found that the number of newborn neurons in the NAc is dynamically regulated by persistent pain, suggesting that adult neurogenesis of MSNs is an experience-modulated process.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Garcia-Gonzalez, ...
-
Dumitru, I
-
Zuccotti, A
-
Yen, TY
-
Herranz-Perez, V
-
Tan, LL
-
show more...
-
Neitz, A
-
Garcia-Verdugo, ...
-
Kuner, R
-
Alfonso, J
-
Monyer, H
-
show less...
- Articles in the publication
-
Molecular psychi ...
- By the university
-
Karolinska Institutet