Search: onr:"swepub:oai:prod.swepub.kib.ki.se:144215256" >
Avoiding dynastic, ...
Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses
- Article/chapterEnglish2020
Publisher, publication year, extent ...
-
2020-07-14
-
Springer Science and Business Media LLC,2020
Numbers
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:144215256
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:144215256URI
-
https://doi.org/10.1038/s41467-020-17117-4DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding from familial effects. Here we describe methods for within-family Mendelian randomization analyses and use simulation studies to show that family-based analyses can reduce such biases. We illustrate empirically how familial effects can affect estimates using data from 61,008 siblings from the Nord-Trøndelag Health Study and UK Biobank and replicated our findings using 222,368 siblings from 23andMe. Both Mendelian randomization estimates using unrelated individuals and within family methods reproduced established effects of lower BMI reducing risk of diabetes and high blood pressure. However, while Mendelian randomization estimates from samples of unrelated individuals suggested that taller height and lower BMI increase educational attainment, these effects were strongly attenuated in within-family Mendelian randomization analyses. Our findings indicate the necessity of controlling for population structure and familial effects in Mendelian randomization studies.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Sanderson, E
(author)
-
Heilbron, K
(author)
-
Hartwig, FP
(author)
-
Harrison, S
(author)
-
Vie, GA
(author)
-
Cho, Y
(author)
-
Howe, LD
(author)
-
Hughes, A
(author)
-
Boomsma, DI
(author)
-
Havdahl, A
(author)
-
Hopper, J
(author)
-
Neale, M
(author)
-
Nivard, MG
(author)
-
Pedersen, NLKarolinska Institutet
(author)
-
Reynolds, CA
(author)
-
Tucker-Drob, EM
(author)
-
Grotzinger, A
(author)
-
Howe, L
(author)
-
Morris, T
(author)
-
Li, S
(author)
-
Auton, A
(author)
-
Windmeijer, F
(author)
-
Chen, WM
(author)
-
Bjorngaard, JH
(author)
-
Hveem, K
(author)
-
Willer, C
(author)
-
Evans, DM
(author)
-
Kaprio, J
(author)
-
Smith, GD
(author)
-
Asvold, BO
(author)
-
Hemani, G
(author)
-
Davies, NM
(author)
-
Karolinska Institutet
(creator_code:org_t)
Related titles
-
In:Nature communications: Springer Science and Business Media LLC11:1, s. 3519-2041-1723
Internet link
Find in a library
To the university's database
- By the author/editor
-
Brumpton, B
-
Sanderson, E
-
Heilbron, K
-
Hartwig, FP
-
Harrison, S
-
Vie, GA
-
show more...
-
Cho, Y
-
Howe, LD
-
Hughes, A
-
Boomsma, DI
-
Havdahl, A
-
Hopper, J
-
Neale, M
-
Nivard, MG
-
Pedersen, NL
-
Reynolds, CA
-
Tucker-Drob, EM
-
Grotzinger, A
-
Howe, L
-
Morris, T
-
Li, S
-
Auton, A
-
Windmeijer, F
-
Chen, WM
-
Bjorngaard, JH
-
Hveem, K
-
Willer, C
-
Evans, DM
-
Kaprio, J
-
Smith, GD
-
Asvold, BO
-
Hemani, G
-
Davies, NM
-
show less...
- Articles in the publication
-
Nature communica ...
- By the university
-
Karolinska Institutet