Search: onr:"swepub:oai:prod.swepub.kib.ki.se:144293914" >
Non-invasive early ...
Non-invasive early detection of cancer four years before conventional diagnosis using a blood test
- Article/chapterEnglish2020
Publisher, publication year, extent ...
-
2020-07-21
-
Springer Science and Business Media LLC,2020
Numbers
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:144293914
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:144293914URI
-
https://doi.org/10.1038/s41467-020-17316-zDOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Early detection has the potential to reduce cancer mortality, but an effective screening test must demonstrate asymptomatic cancer detection years before conventional diagnosis in a longitudinal study. In the Taizhou Longitudinal Study (TZL), 123,115 healthy subjects provided plasma samples for long-term storage and were then monitored for cancer occurrence. Here we report the preliminary results of PanSeer, a noninvasive blood test based on circulating tumor DNA methylation, on TZL plasma samples from 605 asymptomatic individuals, 191 of whom were later diagnosed with stomach, esophageal, colorectal, lung or liver cancer within four years of blood draw. We also assay plasma samples from an additional 223 cancer patients, plus 200 primary tumor and normal tissues. We show that PanSeer detects five common types of cancer in 88% (95% CI: 80–93%) of post-diagnosis patients with a specificity of 96% (95% CI: 93–98%), We also demonstrate that PanSeer detects cancer in 95% (95% CI: 89–98%) of asymptomatic individuals who were later diagnosed, though future longitudinal studies are required to confirm this result. These results demonstrate that cancer can be non-invasively detected up to four years before current standard of care.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Gole, J
(author)
-
Gore, A
(author)
-
He, QY
(author)
-
Lu, M
(author)
-
Min, J
(author)
-
Yuan, ZY
(author)
-
Yang, XR
(author)
-
Jiang, YF
(author)
-
Zhang, TJ
(author)
-
Suo, C
(author)
-
Li, XJ
(author)
-
Cheng, L
(author)
-
Zhang, ZH
(author)
-
Niu, HY
(author)
-
Li, Z
(author)
-
Xie, Z
(author)
-
Shi, H
(author)
-
Zhang, X
(author)
-
Fan, M
(author)
-
Wang, XF
(author)
-
Yang, YJ
(author)
-
Dang, J
(author)
-
McConnell, C
(author)
-
Zhang, J
(author)
-
Wang, JC
(author)
-
Yu, SZ
(author)
-
Ye, WMKarolinska Institutet
(author)
-
Gao, Y
(author)
-
Zhang, K
(author)
-
Liu, R
(author)
-
Jin, L
(author)
-
Karolinska Institutet
(creator_code:org_t)
Related titles
-
In:Nature communications: Springer Science and Business Media LLC11:1, s. 3475-2041-1723
Internet link
Find in a library
To the university's database
- By the author/editor
-
Chen, XD
-
Gole, J
-
Gore, A
-
He, QY
-
Lu, M
-
Min, J
-
show more...
-
Yuan, ZY
-
Yang, XR
-
Jiang, YF
-
Zhang, TJ
-
Suo, C
-
Li, XJ
-
Cheng, L
-
Zhang, ZH
-
Niu, HY
-
Li, Z
-
Xie, Z
-
Shi, H
-
Zhang, X
-
Fan, M
-
Wang, XF
-
Yang, YJ
-
Dang, J
-
McConnell, C
-
Zhang, J
-
Wang, JC
-
Yu, SZ
-
Ye, WM
-
Gao, Y
-
Zhang, K
-
Liu, R
-
Jin, L
-
show less...
- Articles in the publication
-
Nature communica ...
- By the university
-
Karolinska Institutet