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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02955naa a2200421 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:144476996 | |
| 003 | SwePub | |
| 008 | 240701s2020 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1444769962 URI |
| 024 | 7 | a https://doi.org/10.1038/s41598-020-58007-52 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ho, PJ4 aut |
| 245 | 1 0 | a Impact of deviation from guideline recommended treatment on breast cancer survival in Asia |
| 264 | c 2020-01-28 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2020 |
| 520 | a Breast cancer survival has improved with significant progress in treatment and disease management. However, compliance with treatment varies. Treatment guidelines for older patients are unclear. We aim to identify predictors of noncompliance with recommended therapy in a large breast cancer population and assess the impact of noncompliance on survival. Our study included 19,241 non-metastatic female breast cancer patients, of whom 3,158 (16%) died within 10 years post-diagnosis (median survival = 5.8 years). We studied the association between treatment noncompliance and factors with logistic regression, and the impact of treatment noncompliance on survival with a flexible parametric survival model framework. The highest proportion of noncompliance was observed for chemotherapy (18%). Predictors of noncompliance with chemotherapy, radiotherapy and endocrine therapy included age, tumor size, nodal involvement and subtype (except radiotherapy). Factors associated with not receiving surgery included age and subtype. Treatment noncompliance was associated with worse overall survival for surgery (HR: 2.26 [1.80–2.83]), chemotherapy (1.25 [1.11–1.41]), radiotherapy (2.28 [1.94–2.69]) and endocrine therapy (1.70 [1.41–2.04]). Worse survival was similarly observed in older patients for whom guidelines generally do not apply. Our results highlight the importance of following appropriate treatment as recommended by current guidelines. Older patients may benefit from similar recommendations. | |
| 700 | 1 | a Ow, SGW4 aut |
| 700 | 1 | a Sim, YR4 aut |
| 700 | 1 | a Liu, J4 aut |
| 700 | 1 | a Lim, SH4 aut |
| 700 | 1 | a Tan, EY4 aut |
| 700 | 1 | a Tan, SM4 aut |
| 700 | 1 | a Lee, SC4 aut |
| 700 | 1 | a Tan, VKM4 aut |
| 700 | 1 | a Yap, YS4 aut |
| 700 | 1 | a Chay, WY4 aut |
| 700 | 1 | a Tan, BKT4 aut |
| 700 | 1 | a Wong, FY4 aut |
| 700 | 1 | a Li, JM4 aut |
| 700 | 1 | a Hartman, M4 aut |
| 773 | 0 | t Scientific reportsd : Springer Science and Business Media LLCg 10:1, s. 1330-q 10:1<1330-x 2045-2322 |
| 856 | 4 | u https://www.nature.com/articles/s41598-020-58007-5.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:144476996 |
| 856 | 4 8 | u https://doi.org/10.1038/s41598-020-58007-5 |
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