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How to RESPOND to M...
How to RESPOND to Modern Challenges for People Living with HIV: A Profile for a New Cohort Consortium
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Neesgaard, B (author)
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Mocroft, A (author)
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Greenberg, L (author)
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Larsen, JF (author)
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Wandeler, G (author)
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Zangerle, R (author)
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Gunthard, H (author)
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Smith, C (author)
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De Wit, S (author)
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Mussini, C (author)
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Castagna, A (author)
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Monforte, AD (author)
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Vehreschild, JJ (author)
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Wasmuth, JC (author)
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Pradier, C (author)
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Chkhartishvili, N (author)
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Wit, FWNM (author)
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Law, M (author)
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- Sonnerborg, A (author)
- Karolinska Institutet
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Bruguera, A (author)
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Stephan, C (author)
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Vannappagari, V (author)
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Haubrich, R (author)
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Kirk, O (author)
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Podlekareva, D (author)
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Kowalska, J (author)
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Raben, D (author)
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Rockstroh, J (author)
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Peters, L (author)
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Parades, R (author)
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Grabmeier-Pfistershammer, K (author)
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Scherrer, A (author)
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Johnson, M (author)
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Necsoi, C (author)
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Borghi, V (author)
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Muccini, C (author)
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Tserstvadze, T (author)
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Petoumenos, K (author)
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Volny-Anne, A (author)
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Lundgren, J (author)
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Ryom, L (author)
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(creator_code:org_t)
- 2020-07-31
- 2020
- English.
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In: Microorganisms. - : MDPI AG. - 2076-2607. ; 8:8
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https://www.mdpi.com...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- Background: the International Cohort Consortium of Infectious Disease (RESPOND) is a collaboration dedicated to research on HIV and other infectious diseases. Methods: RESPOND is a flexible organization, with several independent substudies operating under one shared governance. HIV-related variables, including full antiretroviral therapy (ART) history, are collected annually for all participants and merged with substudy specific data into a shared data pool. Incident clinical events are reported using standardized forms. Prospective follow-up started 1/10/17 (enrolment) with retrospective data collected back to 01/01/12. Results: Overall, 17 cohorts from Europe and Australia provided data on 26,258 people living with HIV (PLWH). The majority (43.3%) of the population were white, with men-sex-with-men accounting for 43.3% of the risk for HIV acquisition. The median age was 48 years (IQR 40–56) and 5.2% and 25.5% were known to be co-infected with hepatitis B or C. While 5.3% were ART-naïve, the median duration on ART was 10.1 years (4.8–17.6), with 89.5% having a VL <200 copies/mL and the median CD4 count being 621 cells/µL (438–830). Malignancies (n = 361) and cardiovascular disease (n = 168) were the predominant reported clinical events. Conclusion: RESPOND’s large, diverse study population and standardized clinical endpoints puts the consortium in a unique position to respond to the diverse modern challenges for PLWH.
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Neesgaard, B
-
Mocroft, A
-
Greenberg, L
-
Larsen, JF
-
Wandeler, G
-
Zangerle, R
-
show more...
-
Gunthard, H
-
Smith, C
-
De Wit, S
-
Mussini, C
-
Castagna, A
-
Monforte, AD
-
Vehreschild, JJ
-
Wasmuth, JC
-
Pradier, C
-
Chkhartishvili, ...
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Wit, FWNM
-
Law, M
-
Sonnerborg, A
-
Bruguera, A
-
Stephan, C
-
Vannappagari, V
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Haubrich, R
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Kirk, O
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Podlekareva, D
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Kowalska, J
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Raben, D
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Rockstroh, J
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Peters, L
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Parades, R
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Grabmeier-Pfiste ...
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Scherrer, A
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Johnson, M
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Necsoi, C
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Borghi, V
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Muccini, C
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Tserstvadze, T
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Petoumenos, K
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Volny-Anne, A
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Lundgren, J
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Ryom, L
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show less...
- Articles in the publication
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Microorganisms
- By the university
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Karolinska Institutet