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The role of the com...
The role of the comprehensive complication index for the prediction of survival after liver transplantation
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Lai, Q (author)
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Melandro, F (author)
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- Nowak, G (author)
- Karolinska Institutet
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Nicolini, D (author)
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Iesari, S (author)
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Fasolo, E (author)
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Mennini, G (author)
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- Romano, A (author)
- Karolinska Institutet
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Mocchegiani, F (author)
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Ackenine, K (author)
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Polacco, M (author)
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Marinelli, L (author)
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Ciccarelli, O (author)
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Zanus, G (author)
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Vivarelli, M (author)
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Cillo, U (author)
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Rossi, M (author)
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- Ericzon, BG (author)
- Karolinska Institutet
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Lerut, J (author)
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(creator_code:org_t)
- 2020-09-06
- 2021
- English.
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In: Updates in surgery. - : Springer Science and Business Media LLC. - 2038-3312 .- 2038-131X. ; 73:1, s. 209-221
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https://doi.org/10.1...
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Abstract
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- In the last years, several scoring systems based on pre- and post-transplant parameters have been developed to predict early post-LT graft function. However, some of them showed poor diagnostic abilities. This study aims to evaluate the role of the comprehensive complication index (CCI) as a useful scoring system for accurately predicting 90-day and 1-year graft loss after liver transplantation. A training set (n = 1262) and a validation set (n = 520) were obtained. The study was registered at https://www.ClinicalTrials.gov (ID: NCT03723317). CCI exhibited the best diagnostic performance for 90 days in the training (AUC = 0.94; p < 0.001) and Validation Sets (AUC = 0.77; p < 0.001) when compared to the BAR, D-MELD, MELD, and EAD scores. The cut-off value of 47.3 (third quartile) showed a diagnostic odds ratio of 48.3 and 7.0 in the two sets, respectively. As for 1-year graft loss, CCI showed good performances in the training (AUC = 0.88; p < 0.001) and validation sets (AUC = 0.75; p < 0.001). The threshold of 47.3 showed a diagnostic odds ratio of 21.0 and 5.4 in the two sets, respectively. All the other tested scores always showed AUCs < 0.70 in both the sets. CCI showed a good stratification ability in terms of graft loss rates in both the sets (log-rank p < 0.001). In the patients exceeding the CCI ninth decile, 1-year graft survival rates were only 0.7% and 23.1% in training and validation sets, respectively. CCI shows a very good diagnostic power for 90-day and 1-year graft loss in different sets of patients, indicating better accuracy with respect to other pre- and post-LT scores.Clinical Trial Notification: NCT03723317.
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- art (subject category)
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- By the author/editor
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Lai, Q
-
Melandro, F
-
Nowak, G
-
Nicolini, D
-
Iesari, S
-
Fasolo, E
-
show more...
-
Mennini, G
-
Romano, A
-
Mocchegiani, F
-
Ackenine, K
-
Polacco, M
-
Marinelli, L
-
Ciccarelli, O
-
Zanus, G
-
Vivarelli, M
-
Cillo, U
-
Rossi, M
-
Ericzon, BG
-
Lerut, J
-
show less...
- Articles in the publication
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Updates in surge ...
- By the university
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Karolinska Institutet