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NK cell receptor NK...
NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells
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Babic, M (author)
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Dimitropoulos, C (author)
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- Hammer, Q (author)
- Karolinska Institutet
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Stehle, C (author)
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Heinrich, F (author)
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Sarsenbayeva, A (author)
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Eisele, A (author)
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Durek, P (author)
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Mashreghi, MF (author)
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Lisnic, B (author)
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Van Snick, J (author)
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Lohning, M (author)
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Fillatreau, S (author)
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Withers, DR (author)
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Gagliani, N (author)
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Huber, S (author)
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Flavell, RA (author)
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Polic, B (author)
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Romagnani, C (author)
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(creator_code:org_t)
- 2020-05-26
- 2020
- English.
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In: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 217:8
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https://rupress.org/...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- NKG2D is a danger sensor expressed on different subsets of innate and adaptive lymphocytes. Despite its established role as a potent activator of the immune system, NKG2D-driven regulation of CD4+ T helper (Th) cell–mediated immunity remains unclear. In this study, we demonstrate that NKG2D modulates Th1 and proinflammatory T-bet+ Th17 cell effector functions in vitro and in vivo. In particular, NKG2D promotes higher production of proinflammatory cytokines by Th1 and T-bet+ Th17 cells and reinforces their transcription of type 1 signature genes, including Tbx21. Conditional deletion of NKG2D in T cells impairs the ability of antigen-specific CD4+ T cells to promote inflammation in vivo during antigen-induced arthritis and experimental autoimmune encephalomyelitis, indicating that NKG2D is an important target for the amelioration of Th1- and Th17-mediated chronic inflammatory diseases.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Babic, M
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Dimitropoulos, C
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Hammer, Q
-
Stehle, C
-
Heinrich, F
-
Sarsenbayeva, A
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show more...
-
Eisele, A
-
Durek, P
-
Mashreghi, MF
-
Lisnic, B
-
Van Snick, J
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Lohning, M
-
Fillatreau, S
-
Withers, DR
-
Gagliani, N
-
Huber, S
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Flavell, RA
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Polic, B
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Romagnani, C
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show less...
- Articles in the publication
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The Journal of e ...
- By the university
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Karolinska Institutet