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Vitamin C and E Treatment Blunts Sprint Interval Training-Induced Changes in Inflammatory Mediator-, Calcium-, and Mitochondria-Related Signaling in Recreationally Active Elderly Humans
- Wyckelsma, VL (author)
- Venckunas, T (author)
- Brazaitis, M (author)
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- Snieckus, A (author)
- Eimantas, N (author)
- Baranauskiene, N (author)
- Subocius, A (author)
- Skurvydas, A (author)
- Paasuke, M (author)
- Gapeyeva, H (author)
- Kaasik, P (author)
- Paasuke, R (author)
- Jurimae, J (author)
- Graf, BA (author)
- Kayser, B (author)
- Place, N (author)
- Kamandulis, S (author)
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- (creator_code:org_t)
- 2020-09-17
- 2020
- English.
- In: Antioxidants (Basel, Switzerland). - : MDPI AG. - 2076-3921. ; 9:9
- Journal article (peer-reviewed)
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- Sprint interval training (SIT) has emerged as a time-efficient training regimen for young individuals. Here, we studied whether SIT is effective also in elderly individuals and whether the training response was affected by treatment with the antioxidants vitamin C and E. Recreationally active elderly (mean age 65) men received either vitamin C (1 g/day) and vitamin E (235 mg/day) or placebo. Training consisted of nine SIT sessions (three sessions/week for three weeks of 4-6 repetitions of 30-s all-out cycling sprints) interposed by 4 min rest. Vastus lateralis muscle biopsies were taken before, 1 h after, and 24 h after the first and last SIT sessions. At the end of the three weeks of training, SIT-induced changes in relative mRNA expression of reactive oxygen/nitrogen species (ROS)- and mitochondria-related proteins, inflammatory mediators, and the sarcoplasmic reticulum Ca2+ channel, the ryanodine receptor 1 (RyR1), were blunted in the vitamin treated group. Western blots frequently showed a major (>50%) decrease in the full-length expression of RyR1 24 h after SIT sessions; in the trained state, vitamin treatment seemed to provide protection against this severe RyR1 modification. Power at exhaustion during an incremental cycling test was increased by ~5% at the end of the training period, whereas maximal oxygen uptake remained unchanged; vitamin treatment did not affect these measures. In conclusion, treatment with the antioxidants vitamin C and E blunts SIT-induced cellular signaling in skeletal muscle of elderly individuals, while the present training regimen was too short or too intense for the changes in signaling to be translated into a clear-cut change in physical performance.
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- Wyckelsma, VL
- Venckunas, T
- Brazaitis, M
- Gastaldello, S
- Snieckus, A
- Eimantas, N
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- Baranauskiene, N
- Subocius, A
- Skurvydas, A
- Paasuke, M
- Gapeyeva, H
- Kaasik, P
- Paasuke, R
- Jurimae, J
- Graf, BA
- Kayser, B
- Place, N
- Andersson, DC
- Kamandulis, S
- Westerblad, H
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- Karolinska Institutet
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