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Vaccine elicitation...
Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells
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Huang, DL (author)
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Tran, JT (author)
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Olson, A (author)
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Vollbrecht, T (author)
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Tenuta, M (author)
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- Guryleva, MV (author)
- Karolinska Institutet
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Fuller, RP (author)
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Schiffner, T (author)
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Abadejos, JR (author)
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Couvrette, L (author)
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Blane, TR (author)
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Saye, K (author)
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Li, WJ (author)
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Landais, E (author)
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Gonzalez-Martin, A (author)
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Schief, W (author)
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- Murrell, B (author)
- Karolinska Institutet
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Burton, DR (author)
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Nemazee, D (author)
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Voss, JE (author)
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(creator_code:org_t)
- 2020-11-17
- 2020
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 5850-
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Abstract
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- HIV broadly neutralizing antibodies (bnAbs) can suppress viremia and protect against HIV infection. However, their elicitation is made difficult by low frequencies of appropriate precursor B cell receptors and the complex maturation pathways required to generate bnAbs from these precursors. Antibody genes can be engineered into B cells for expression as both a functional antigen receptor on cell surfaces and as secreted antibody. Here, we show that HIV bnAb-engineered primary mouse B cells can be adoptively transferred and vaccinated in immunocompetent mice resulting in the expansion of durable bnAb memory and long-lived plasma cells. Somatic hypermutation after immunization indicates that engineered cells have the capacity to respond to an evolving pathogen. These results encourage further exploration of engineered B cell vaccines as a strategy for durable elicitation of HIV bnAbs to protect against infection and as a contributor to a functional HIV cure.
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- art (subject category)
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- By the author/editor
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Huang, DL
-
Tran, JT
-
Olson, A
-
Vollbrecht, T
-
Tenuta, M
-
Guryleva, MV
-
show more...
-
Fuller, RP
-
Schiffner, T
-
Abadejos, JR
-
Couvrette, L
-
Blane, TR
-
Saye, K
-
Li, WJ
-
Landais, E
-
Gonzalez-Martin, ...
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Schief, W
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Murrell, B
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Burton, DR
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Nemazee, D
-
Voss, JE
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show less...
- Articles in the publication
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Nature communica ...
- By the university
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Karolinska Institutet